蔡莉，女，博士，副教授，硕士研究生导师。中国医师协会病理科医师分会青年委员，安徽医科大学校中青年学术技术带头人后备人选。2005年至今一直在安徽医科大学病理学教研室及第一/二附属医院病理科从事病理学教学、科研及临床外检工作。主要研究方向为类风湿关节炎、抑郁症的发病机制及药物药理学研究，曾主持完成1项国家自然科学基金青年项目和2项省部级课题，正在主持1项安徽省自然科学基金面上项目和1项炎症免疫性疾病安徽省实验室开放课题，以第一/通讯作者发表SCI论文20余篇，获安徽省教育厅“高校优秀青年人才”、安徽医科大学“优秀青年教师”、安徽医科大学“教坛新秀”等称号，研究成果获安徽省第七/八届自然科学优秀学术论文二等奖。

教育背景

1997.07-2001.06   山东大学，临床医学学士；

2002.07-2005.06   山东大学，病理学硕士；

2007.07-2011.06   中国科学技术大学，生物学博士；

1. 安徽省自然科学基金面上项目(2108085MH321)，吡啶甲酰胺类化合物AMSP-30m 通过HIF-1α-Shh-Gli1 信号轴调控成纤维样滑膜细胞活化在类风湿关节炎治疗中的机制研究， 2021.1-2023.12，主持；

2. 国家自然科学基金面上项目（81972040）：水通道蛋白1通过Wnt/β-catenin通路调控FLS活化参与类风湿关节炎发病的机制研究，2020.01- 2023.12，主要参与人（第二）；

3. 国家自然科学基金青年项目(81201052)，视黄酸受体调控谷氨酸受体介导下丘脑CRH神经元树突修饰在抑郁症发病中的作用及机制研究，2013.1-2015.12，主持；

4. 安徽省自然科学基金青年项目(1208085QH149)，视黄酸受体经由GluR1介导抑郁症下丘脑CRH神经元突触重塑及其非基因组机制， 2011.1-2013.12，主持；

5. 安徽省高校省级优秀青年人才基金项目(2009SQRZ041ZD)，人APOE不同基因型对神经血管单元的影响及其分子机制，2009.1-2011.12，主持；

1. Xing, Si-qi^#; Fan, Wei-zheng^#; Chen, Jun-hua^#; Du, Ji-yu; Liu, Tong-tong; Dong, Shuang-hong; Xia, Ju-cheng; Liu, Pei-pei; Zou, De-xing; Cai, Li^*; Li, Zeng^*. Novel quinoline-based derivatives: A new class of PDE4B inhibitors for adjuvant-induced arthritis. European Journal of Medicinal Chemistry, 2022, 238, 114497.

2. Cai, Li; Li, Yan-li; Hu, Xiang-yang; Li, Rong^*. Implementation of flipped classroom combined with case-based learning: A promising and effective teaching modality in undergraduate pathology education. Medicine (Baltimore), 2022, 101(5): e28782.

3. Meng, Bo^#; Liu, Fang-yuan^#; Liu, Ming-ming^#; Yu, Liang-chen; Zhang, Wen-ting; Zhou, Meng-yuan; Liu, Si-yu; Li, Rong^*; Cai, Li^*. AMSP-30m as a novel HIF-1α inhibitor attenuates the development and severity of adjuvant-induced arthritis in rats: Impacts on synovial apoptosis, synovial angiogenesis and sonic hedgehog signaling pathway. International Immunopharmacology, 2022, 103, 108467

4. Cai, Li^#; Zong Pan^#; Zhou, Meng-yuan; Liu, Fang-yuan; Meng, Bo; Liu, Ming-ming^*; Li, Zeng^*; Li, Rong^*. 7-Hydroxycoumarin mitigates the severity of collagen-induced arthritis in rats by inhibiting proliferation and inducing apoptosis of fibroblast-[like] synoviocytes via suppression of Wnt/β-catenin signaling pathway. Phytomedicine, 2022, 94: 153841.

5. Cai, Li^#; Mu, Yu-rong^#; Liu, Ming-ming^#; Zhou, Meng-yuan; Meng, Bo; Liu, Fang-yuan; Li, Rong^*. Penta-acetyl geniposide suppresses migration, invasion, and inflammation of TNF-α-stimulated rheumatoid arthritis fibroblast-[like] synoviocytes involving Wnt/β-Catenin signaling pathway. Inflammation, 2021, 44(6):2232-2245.

6. Zhou, Meng-yuan^#; Cai, Li^#; Feng, Xiao-wen; Mu, Yu-rong; Meng, Bo; Liu, Fang-yuan; Li, Rong^*. Lentivirus-mediated overexpression or silencing of aquaporin 1 affects the proliferation, migration and invasion of TNF-α-stimulated rheumatoid arthritis fibroblast-[like] synoviocytes by Wnt/β-catenin signaling pathway. Journal of Inflammation Research, 2021, 14: 1945-1957.

7. Mu, Yu-rong^#; Cai, Li^#; Zhou, Meng-yuan; Liu, Ming-ming; Li, Zeng; Li, Rong^*. Acetazolamide ameliorates the severity of collagen-induced arthritis in rats: Involvement of inducing synovial apoptosis and inhibiting Wnt/β-catenin pathway. International Immunopharmacology, 2021, 90: 107214.

8. Cai, Li^#; Mu, Yu-rong^#; Liu, Ming-ming; Tang, Wen-jian; Li, Rong^*. Antidepressant-[like] effects of penta-acetyl geniposide in chronic unpredictable mild stress-induced depression rat model: Involvement of inhibiting neuroinflammation in prefrontal cortex and regulating hypothalamic-pituitaryadrenal axis. International Immunopharmacology, 2020, 80: 106182.

9. Cai, Li^#; Li, Chun-mei ^#; Chen, Wei-na; Qiu, Yuan-ye; Guo, Yan-li; Li, Rong^*. Penta-acetyl geniposide induces apoptosis of fibroblast-[like] synoviocytes from adjuvant-induced arthritis rats in vitro, associated with inhibition of NF-κB activation. Pharmacological Reports, 2019, 71(6):1006-1013.

10. Ke, Qi^#; Li, Rong^#; Cai, Li^*; Wu, Sheng-dong; Li, Chun-mei. Ro41-5253, a selective antagonist of retinoic acid receptor α, ameliorates chronic unpredictable mild stress-induced depressive-[like] behaviors in rats: Involvement of regulating HPA axis and improving hippocampal neuronal deficits. Brain Research Bulletin, 2019, 146: 302-309.

11. Cai, Li^#; Li, Chun-mei^#; Tang, Wen-jian; Liu, Ming-ming; Chen, Wei-na; Qiu, Yuan-ye; Li, Rong^*. Therapeutic effect of penta-acetyl geniposide on adjuvant-induced arthritis in rats: Involvement of inducing synovial apoptosis and inhibiting NF-κB signal pathway. Inflammation, 2018, 41(6): 2184-2195.

12. Cai, Li^#; Chen, Wei-na^#; Li, Rong^*; Liu, Ming-ming; Lei, Chao; Li, Chun-mei; Qiu, Yuan-ye. Acetazolamide protects rat articular chondrocytes from IL-1β-induced apoptosis by inhibiting the activation of NF-κB signal pathway. Canadian Journal of Physiology and Pharmacology, 2018, 96(11): 1104-1111.

13. Cai, Li^#; Chen, Wei-na^#; Li, Rong^*; Hu, Cheng-mu; Lei, Chao; Li, Chun-mei. Therapeutic effect of acetazolamide, an aquaporin 1 inhibitor, on adjuvant-induced arthritis in rats by inhibiting NF-κB signal pathway. Immunopharmacology and Immunotoxicology, 2018, 40(2): 117-125.

14. Cai, Li^#; Lei, Chao^#; Li, Rong^*; Chen, Wei-na; Li, Chun-mei. Aquaporin-4 blockage by siRNA protects rat articular chondrocytes from IL-1β-induced apoptosis by inhibiting p38 MAPK signal pathway. Annals of Clinical & Laboratory Science, 2017, 47(5): 563-571.

15. Li, Rong^#; Zhao, Xia^#; Cai, Li^*; Gao, Wan-wan. Up-regulation of GluR1 in paraventricular nucleus and greater expressions of synapse related proteins in the hypothalamus of chronic unpredictable stress-induced depressive rats. Physiology & Behavior, 2017, 179: 451-457.

16. Cai, Li^#; Lei, Chao^#; Li, Rong^*; Chen, Wei-na; Hu, Cheng-mu; Chen, Xiao-yu; Li, Chun-mei. Overexpression of aquaporin 4 in articular chondrocytes exacerbates the severity of adjuvant-induced arthritis in rats: an in vivo and in vitro study. Journal of Inflammation-London, 2017, 14: 6.

17. Li, Rong; Cai, Li^*; Tang, Wen-jian; Lei, Chao; Hu, Cheng-mu; Yu, Fang. Apoptotic effect of geniposide on fibroblast-[like] synoviocytes in rats with adjuvant-induced arthritis via inhibiting ERK signal pathway in vitro. Inflammation, 2016, 39(1): 30-38.

18. Cai, Li; Li, Rong^*; Tang, Wen-jian; Meng, Gang; Hu, Xiang-yang; Wu, Ting-ni. Antidepressant-[like] effect of geniposide on chronic unpredictable mild stress-induced depressive rats by regulating the hypothalamus-pituitary-adrenal axis. European Neuropsychopharmacology, 2015, 25(8): 1332-1341.

19. Li, Rong; Cai, Li^*; Ding, Jing; Hu, Cheng-mu; Wu, Ting-ni; Hu, Xiang-yang. Inhibition of hedgehog signal pathway by cyclopamine attenuates inflammation and articular cartilage damage in rats with adjuvant-induced arthritis. Journal of Pharmacy and Pharmacology, 2015, 67(7): 963-971

20. Li, Rong; Cai, Li^*; Hu, Cheng-mu; Wu, Ting-ni; Li, Jun. Expression of hedgehog signal pathway in articular cartilage is associated with the severity of cartilage damage in rats with adjuvant-induced arthritis. Journal of Inflammation-London, 2015, 12: 24.

21. Cai, Li; Li, Rong; Zhou, Jiang-ning^*. Chronic all-trans retinoic acid administration induces CRF over-expression accompanied by AVP up-regulation and multiple CRF-controlling receptors disturbance in the hypothalamus of rats. Brain Research, 2015, 1601: 1-7.

22. Cai, Li; Yan, Xue-bo; Chen, Xiao-ning; Meng, Qing-yuan; Zhou, Jiang-ning^*. Chronic all-trans retinoic acid administration induced hyperactivity of HPA axis and behavioral changes in young rats. European Neuropsychopharmacology, 2010, 20(12): 839-847.

1. 安徽省第七届自然科学优秀学术论文（安徽省科学技术协会/安徽省科学技术厅/安徽省人力资源和社会保障厅），二等奖，2013年。（李荣, 蔡莉, 解雪峰）

2. 安徽省第八届自然科学优秀学术论文（安徽省科学技术协会/安徽省科学技术厅/安徽省人力资源和社会保障厅），二等奖，2016年。（李荣, 蔡莉, 李俊）