叶艳，女，教授，博士研究生导师，基础医学院免疫学教研室副主任，安徽省医学会微生物与免疫学分会青年委员。

1998.09-2003.07 安徽医科大学，医学系，临床医学专业，学士

2003.09-2006.06 安徽医科大学，基础医学院，免疫学专业，硕士

2006.06-2009.06 安徽医科大学，基础医学院，免疫学教研室，助教

2009.07-2014.10 安徽医科大学，基础医学院，免疫学教研室，讲师

2010.07-2011.12 澳大利亚纽卡斯尔大学，肿瘤免疫实验室，访问学者

2010.09-2013.06 安徽医科大学，基础医学院，免疫学专业，博士

2014.11-2020.11 安徽医科大学，基础医学院，免疫学教研室，副教授

2020.12-至今       安徽医科大学，基础医学院，免疫学教研室，教授

1. Prohibitin-2通过影响SHIP2蛋白的稳定性促进胃癌进展和转移。 国家自然科学基金面上项目。56万元。在研。主持

2. 组蛋白去乙酰化下调表达多磷酸肌醇5-磷酸酶SHIP2 在胃癌发生和发展中的作用。 国家自然科学基金青年基金资助项目。23万元。已结题。主持

3. PHB2在胃癌细胞上调表达的功能性意义及其转录调控机制。安徽省自然科学基金面上项目。12万元。在研。主持

4. 组蛋白去乙酰化下调多磷酸肌醇5-磷酸酶SHIP2表达对胃癌细胞生物学功能的影响及其作用机制。安徽省自然科学基金青年基金资助项目。7万元。已结题。主持

5. SHIP2在胃癌侵袭和转移中的作用及其分子机制。安徽省高校优秀青年人才支持计划重点项目。6万元。已结题。主持

6. SHIP2在胃癌细胞中表达下调的功能性意义及其转录调控机制。安徽医科大学国家优秀青年科学基金获得者培育计划资助项目。40万元。已结题。主持

1. Lin Ren, Li Meng, Jing Gao, Mingdian Lu, Chengyu Guo, Yunyun Li , Ziye Rong*, Yan Ye*. PHB2 promotes colorectal cancer cell proliferation and tumorigenesis through NDUFS1-mediated oxidative phosphorylation. Cell Death Dis. 2023, 14(1):44. (*Correspondence author)

2. Li Chen, Daoai Wu, Lili Zhou, Yan Ye*. Platelet-rich plasma promotes diabetic ulcer repair through inhibition of ferroptosis. Ann Transl Med. 2022, 10(20):1121. (*Correspondence author)

3. Liang Xu, Yuling Shao, Lin Ren, Xiansheng Liu, Yunyun Li, Jiegou Xu, Yan Ye*. IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via Elevating SHIP2 Phosphatase Activity. Int J Mol Sci. 2020, 21(6):1968. (*Correspondence author)

4. Guo K, Li LL, Zhang Q, Yu JM*, Ye Y*. Diversified Variants of Astrovirus MLB2 in Patients Following Hematopoietic Stem Cell Transplantation and the Evolutionary Rates and Patterns of the Virus. Evol Bioinform. 2019, 15:1-6.  (*Correspondence author)

5. Ye Y*, Qian XY, Xiao MM, Shao YL, Guo LM, Liao DP, Da J, Zhang LJ, Xu J*.  Decreased Sp1 Expression Mediates Downregulation of SHIP2 in Gastric Cancer Cells. Int J Mol Sci. 2017, 18(1):220. (*Correspondence author)

6. Ye Y, Ge YM, Xiao MM, Guo LM, Li Q, Hao JQ, Da J, Hu WL, Zhang XD, Xu J*, Zhang LJ*. Suppression of SHIP2 contributes to tumorigenesis and proliferation of gastric cancer cells via activation of Akt. J Gastroenterol. 2016, 51(3):230-240.

7. Chi M, Ye Y, Zhang XD*, Chen J*. Insulin induces drug resistance in melanoma through activation of the PI3K/Akt pathway. Drug Des Devel Ther. 2014, 8:255-62.

8. Chi M, Chen J, Ye Y, Tseng HY, Lai F, Tay KH, Jin L, Guo ST, Jiang CC, Zhang XD*. Adipocytes Contribute to Resistance of Human Melanoma Cells to Chemotherapy and Targeted Therapy. Curr Med Chem. 2014, 21(10):1255-1267.

9. Ye Y, Li Q, Hu WL, Tseng HY, Jin L, Zhang XD*, Zhang LJ*, Yang S*. Loss of PI(4,5)P2 5-Phosphatase A Contributes to Resistance of Human Melanoma Cells to RAF/MEK Inhibitors. Transl Oncol. 2013, 6(4):470-481.

10. Ye Y, Jin L, Wilmott JS, Hu WL, Yosufi B, Thorne RF, Liu T, Rizos H, Yan XG, Dong L, Tay KH, Tseng HY, Guo ST, de Bock CE, Jiang CC, Wang CY, Wu M,Zhang LJ, Hersey P, Scolyer RA, Zhang XD*. PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma. Nat Commun. 2013, 4:1508.

11. Tay KH, Jin L, Tseng HY, Jiang CC, Ye Y, Thorne RF, Liu T, Guo ST, Verrills NM, Hersey P, Zhang XD*. Suppression of PP2A is critical for protection of melanoma cells upon endoplasmic reticulum stress. Cell Death Dis. 2012, 3: e337.

12. Tseng HY, Chen LH, Ye Y, Tay KH, Jiang CC, Guo ST, Jin L, Hersey P*, Zhang XD*. The Melanoma-Associated Antigen MAGE-D2 Suppresses TRAIL Receptor 2 and Protects against TRAIL-Induced Apoptosis in Human Melanoma Cells. Carcinogenesis. 2012, 33(10):1871-1881.

13. Zhan Z, Li Q, Wu P, Ye Y, Tseng HY, Zhang L*, Zhang XD*. Autophagy-mediated HMGB1 release antagonizes apoptosis of gastric cancer cells induced by vincristine via tranional regulation of Mcl-1. Autophagy. 2012, 8(1):109-121.

14. 《病原生物学与免疫学》. 高职高专规划教材. 北京师范大学出版集团安徽大学出版社. 主编,  2018.