吴强教授，博士生导师，安徽省学术与技术带头人、安徽省教学名师。安徽省抗癌协会肿瘤病理专业委员会主任委员、安徽省临床肿瘤学会肿瘤病理专业委员会候任主委、安徽省医学会妇科肿瘤学分会常务委员、中国医师协会病理科医师分会委员、中国教育国际交流协会理事、中国教育国际交流协会国际医学教育分会副理事长。多年来一直从事乳腺癌的研究，先后主持国家自然科学研究基金3项，主要致力于非编码RNA对乳腺癌生物学行为的影响及机制研究、肿瘤微环境中性粒细胞与肿瘤细胞间的相互作用对乳腺癌生物学行为影响的研究以及人工智能辅助病理诊断研究，为肿瘤病理诊断、预后判断及治疗提供新思路。在Int J Cancer、J Leukoc Biol等杂志发表论文一百余篇，获安徽省科技进步奖3项、国家发明专利优秀奖1项。

教育和工作经历

1. 1981.09-1986.06   安徽医科大学临床医学系 临床医学专业 学士

2. 1986.09-1989.06   安徽医科大学基础医学部 病理学专业 硕士

3. 1989.07-至今         安徽医科大学病理学教研室暨附属医院病理科 助教、讲师、副教授、教授

4. 2000.09-2003.06   安徽医科大学临床药理研究所 药理学专业 博士

5. 2005.10-2006.01   韩国高丽大学医学院病理学系暨附属安岩医院病理科 访问教授

6. 2011.07-2011.08   韩国高丽大学附属九老医院病理科 访问学者

7. 2012.07-2012.09   澳大利亚塔斯马尼亚大学孟席斯医学研究所 访问学者

1. 2022年度合肥市自然科学基金，2022037，肿瘤相关中性粒细胞通过分泌lncRNA影响乳腺癌的进展，2022/07- 2024/06，在研，主持

2. 安徽省教育厅2021年度高校科学研究重大项目，KJ2021ZD0018，肿瘤浸润中性粒细胞与淋巴细胞比率预测乳腺癌患者预后并制作免疫组化双染试剂盒，202201-202312，在研，主持

3. 国家留学基金管理委员会，促进与加拿大、澳大利亚、新西兰及拉美地区合作与高层次人才培养项目，乳腺癌生物学行为研究中澳合作及高层次人才培养项目，2020.1-2022.1，已结题，主持

4. 安徽人力资源和社会保障厅，学术和技术带头人后备人选科研活动经费，2019H230，乳腺癌侵袭转移相关circRNAs的鉴定、甄选及临床应用研究，2019-01至2021-12，已结题，主持

5. 安徽省转化医学研究院，B类，2017zhyx36，circRNA 100683在HER2阳性乳腺癌中的临床作用，2018.1-2020.12，已结题，主持

6. 国家自然科学基金委员会，面上项目，81372476，miRNA在乳腺癌抗HER-2靶向治疗耐药中对HER-2蛋白表达的调控机制，2014.01-2017.12，已结题，主持

7. 国家自然科学基金委员会，面上项目，81172533，miR-133a参与乳腺癌侵袭转移的调控及其机制，2012.01-2014.12，已结题，主持

8. 国家自然科学基金委员会，面上项目，30873047，针对 MMP-9 靶基因的miRNAs 筛选及外源性miRNAs 干扰MMP-9 表达对乳腺癌侵袭转移的影响，2009.01-2011.12，已结题，主持

1. Youjing Sheng, Weidong Peng , Yan Huang, Lanqing Cheng, Ye Meng, Louis Boafo Kwantwi, Jiezhen Yang, Jiegou Xu, Han Xiao, Julia Kzhyshkowska, Qiang Wu（通讯作者）. Tumor-activated neutrophils promote metastasis in breast cancer via the G-CSF-RLN2-MMP-9 axis. J Leukoc Biol. 2023 Mar 29;113(4):383-399.

2. Lin Ang, Jiang Li, Hui Dong, Chunhong Wang, Jin Huang, Mingcong Li, Min Zhao, Changqing Su, Qiang Wu（通讯作者）. Chimeric Oncolytic Adenovirus Armed Chemokine Rantes for Treatment of Breast Cancer. Bioengineering (Basel). 2022 Jul 26;9(8):342.

3. Weidong Peng, Youjing Shen, Han Xiao, Yuanzi Ye, Louis Boafo Kwantwi, Lanqing Cheng, Yuanchong Wang, Jiegou Xu, Qiang Wu（通讯作者）. Lung Adenocarcinoma Cells Promote Self-Migration and Self-Invasion by Activating Neutrophils to Upregulate Notch3 Expression of Cancer Cells. Front Mol Biosci. 2022 Jan 18;8:762729.

4. Louis Boafo Kwantwi, Shujing Wang, Wenjun Zhang, Weidong Peng, Zeyu Cai, Youjing Sheng, Han Xiao, Xian Wang, Qiang Wu（通讯作者）. Tumor-associated neutrophils activated by tumor-derived CCL20 (C-C motif chemokine ligand 20) promote T cell immunosuppression via programmed death-ligand 1 (PD-L1) in breast cancer. Bioengineered. 2021 Dec;12(1):6996-7006.

5. Jing Wang, Xiaona Fang, Chenchen Zhang, Haishuo Ji, Qiushi Pang, Xuqing Li, Zhaofeng Luo, Qiang Wu （通讯作者）, Liyun Zhang. Development of Aptamer-Based Molecular Tools for Rapid Intraoperative Diagnosis and In Vivo Imaging of Serous Ovarian Cancer. ACS Appl Mater Interfaces. 2021 Apr 14;13(14):16118-16126.

6. Zeyu Cai, Mingxun Zhang, Louis Boafo Kwantwi, Xiaomin Bi, Zhongle Cheng, Xiaojuan Ding, Tianhong Su, Hua Wang, Qiang Wu (通讯作者). Breast cancer cells promote self-migration by secreting interleukin 8 to induce NET formation. Gene, 2020 Jun 13;754:144902.

7. Zhongle Cheng , Wei Wei, Zhengsheng Wu, Jing Wang, Xiaojuan Ding, Youjing Sheng, Yinli Han, Qiang Wu（通讯作者）. ARPC2 promotes breast cancer proliferation and metastasis. Oncol Rep, 2019 Jun;41(6):3189-3200.

8. Jing Wang, Yonghong Song, Mingxun Zhang, Zhengsheng Wu, Yun-Jun Xu, Jun Lin, Daishun Ling, Youjin Sheng, Yang Lu, Qiang Wu（通讯作者）. Liposomal curcumol nanocomposite for magnetic resonance imaging and endoplasmic reticulum stress mediated chemotherapy of human primary ovarian cancer. J Mater Chem B, 2019 Apr, 7: 2938-2947.

9. Xiaojuan Huang, Yu Xia, Guifang He, Lulu Zheng ,Yongping Cai, Yu Yin, Qiang Wu（通讯作者）. MALAT1 promotes angiogenesis of breast cancer. Oncol Rep, 2018 Aug 5;40: 2683-2689.

10. Xian Wang, Dongrui Jiang, Chengchen Xu, Guilu Zhu, Zhengsheng Wu, Qiang Wu（通讯作者）. Differential expression profile analysis of miRNAs with HER-2 overexpression  intervention in breast cancer cells. Int J Clin Exp Pathol. 2017;10(5):5039-5062.

11. Qiang Wu, Hong Yan , Siqi Tao, Xiaonan Wang , Lang Mou , Ping Chen ,Xingwang Cheng , Wenyong Wu , Zheng-sheng Wu.XIAP 3'-untranslated region as a ceRNA promotes FSCN1 function in inducing the progression of breast cancer by binding endogenous miR-29a-5p. Oncotarget, 2017; 8 (10): 16784-16800.

12. Hong Yan, Min Zhao, Shan Huang, Ping Chen, Wen-yong Wu, Jin Huang, Zheng-sheng Wu, Qiang Wu（通讯作者）. Prolactin Inhibits BCL6 Expression in Breast Cancer Cells through a MicroRNA-339-5p-Dependent Pathway. J Breast Cancer. 2016;19(1): 26-33.

13. Fei Fei, Dan Zhang, Zhengduo Yang, Shujing Wang, Xian Wang, Zhengsheng Wu, Qiang Wu（通讯作者）, Zhang Shiwu. The number of polyploid giant cancer cells epithelial-mesenchymal transitionrelated proteins are associated with invasion metastasis in human breast cancer. J Exp Clin Cancer Res. 2015 Dec 24;34(1):158.

14. Xiaonan Wang, Shujing Wang, Vijay Pandey, Ping Chen, Qing Li, Zhengsheng Wu, Qiang Wu（通讯作者）, Peter E. Lobie. Trefoil factor 3 as a novel biomarker to distinguish between adenocarcinoma and squamous cell carcinoma. Medicine. 2015; 94 (20): 1-10.

15. Yu Yin, Tao Wang, Yongping Cai, Xiaojuan Huang, Yujie Li, Shunhua Chen, Rong Qin, Chaofu Wan, and Qiang Wu（通讯作者）. Microcystic/Reticular Schwannoma of the Mandible First Case Report and Review of the Literature. Medicine (Baltimore), 2015 Nov; 94(45):e1974.

16. Qiang Wu, Xue Liu, Hong Yan, Yinhuan He, Shan Ye, Xingwang Cheng  Guilu Zhu, Wenyong Wu, Xiaonan Wang, Xiangjun Kong, Xiaochun Xu, Peter E Lobie , Taozhu, Zhengsheng Wu. B-cell lymphoma 6 protein stimulates oncogenicity of human breast cancer cells. BMC Cancer. 2014; 14(1):418.

17. Haidan Jin, Minghua Cui, Jienan Kong, Xuelian Cui, ZhenhuaLin, Qiang Wu（通讯作者）, Shuangping Liu. Sineoculis homeobox homolog 1 protein is associated with breast cancer progression and survival outcome. Exp. Mol. Pathol, 2014; 97(1): 247–252.

18.  Zheng-sheng Wu, Chao-qun Wang, Ru Xiang, Xue Liu, Shan Ye, Xue-qing Yang, Gui-hong Zhang, Xiao-chun Xu, Tao Zhu, Qiang Wu（通讯作者）. Loss of miR-133a expression associated with poor survival of breast cancer and restoration of miR-133a expression inhibited breast cancer cell growth and invasion.  BMC Cancer. 2012 Feb 1;12:51.

19. Gao Yi, Wu Qiang（通讯作者）, Wu Zhengsheng, Zhang Guihong, Zhang Anli, Yang F. Effects of an engineered anti-HER2 antibody chA21 on invasion of human ovarian carcinoma cell in vitro. Chin J Cancer Res, 2011; 23(2). 147-152.

20. AnLi Zhang, Hua Xue，XiaoGuang Ling, Yi Gao, Feng Yang, LianSheng Cheng, Jing Liu, Qiang Wu（通讯作者）. Anti-HER-2 engineering antibody ChA21 inhibits growth and induces apoptosis of SK-OV-3 cells. Journal of Experimental & Clinical Cancer Research. 2010, 29:23

21. Zhang A, Shen G, Zhao T, Zhang G, Liu J, Song L, Wei W, Bing L, Wu Z, Wu Q（通讯作者）. Augmented inhibition of angiogenesis by combination of HER2 antibody chA21 and trastuzumab in human ovarian carcinoma xenograft. J Ovarian Res. 2010,19;3:20

22. Zheng-sheng Wu, Qiang Wu（通讯作者）, Chao-qun Wang, Xiao-nan Wang, Yan Wang, Jing-jing Zhao, Shan-shan Mao, Gui-hong Zhang, Nong Zhang, Xiao-chun Xu. MiR-339-5p inhibits breast cancer cell migration and invasion in vitro may be a potential biomarker for breast cancer prognosis. BMC Cancer. 2010, 10:542

1.    肿瘤蛋白p185检测试剂盒，2016年国家发明专利，专利号：ZL 2013 1 0718223.7。第四发明人

2.    人肿瘤抗原P185的制备和检测方法，2005年国家发明专利，专利号：ZL 01 1 13787.8。第三发明人

3.    p185neu/c-erbB-2单克隆抗体杂交瘤其制备方法及肿瘤检测用途，2003年国家发明专利，专利号：ZL 98116523.0。第五发明人

1. 2016年安徽省科学技术奖（科技进步奖）三等奖，项目负责人

2. 2010安徽省科学技术奖（科技进步奖）三等奖，第二完成人

3. 2010中国专利奖优秀奖，第五完成人