张素梅，女，基础医学院生物化学与分子生物学教研室副教授。

教育经历

2006.09-2009.07  安徽医科大学， 药理学， 博士， 导师：汪渊

2000.09-2003.07  安徽医科大学，生物化学与分子生物学， 硕士，导师：汪渊

1995.09-2000.07  安徽医科大学， 临床医学， 学士

工作经历

2012.07-至今        安徽医科大学，基础医学院生物化学与分子生物学教研室，副教授

2017.09-2018.06  佛罗里达州立大学（FSU），访问学者，合作导师：邓武民教授

2006.07-2012.06  安徽医科大学，基础医学院生物化学与分子生物学教研室，讲师

2004.09-2005.09  加州大学洛杉矶分校（UCLA），博士后，合作导师：Joe D Kopple

2003.07-2006.06  安徽医科大学，基础医学院生物化学与分子生物学教研室，助教

1. 安徽省自然科学基金项目，1708085MH212，endocan通过其介导的细胞间紧密连接重塑抑制胃癌细胞侵袭转移及机制的研究，2017-07至2019-06，已结题，主持。

2. 国家自然科学基金青年基金项目，81201907，endocan对胃癌细胞生物学行为的影响及其机制的研究，2013-01至2015-12，已结题，主持。

3. 安徽省高等学校优秀青年人才基金项目，2012SQRL067，褪黑素诱导胃癌细胞分化过程中endocan的作用，2012-01至2013-12，已结题，主持。

1. Jia Ning, Tong Hanxing, Zhang Yong, Katayama Hiroshi, Wang Yuan, Lu weiqi, Zhang Sumei, Wang Jin. CeRNA Expression Profiling Identifies KIT-Related circRNA-miRNA-mRNA Networks in Gastrointestinal Stromal Tumour. Front Genet. 2019; 10:825.

2. Wei Xiang, Chen Shaolong, Xu Zhe, Jia Ning, Qi Yinliang, Zhou Qing, Wang Jian, Qu Lijun, Zhang Sumei, Wang Yuan. Melatonin inhibits the migration of human gastric carcinoma cells at least in part by remodeling tight junction. J Cell Biochem. 2019;120(6):9781-9786.

3. Yongsheng Wang, Qi Yinliang, Wei Xiang, Chen Shaolon, Jia Ning, Zhou Qing, Zhang Sumei, Gui Shuyu, Wang Yuan. Hyperbaric oxygen rescues lung cancer cells from chemical hypoxia-induced low differentiation [and] apoptosis resistance. Exp Lung Res. 2018;44(8-9):417-423.

4. Wei Xiang, Qi Yinliang, Jia Ning, Zhou Qing, Zhang Sumei, Wang Yuan. Hyperbaric oxygen treatment sensitizes gastric cancer cells to melatonin-induced apoptosis through multiple pathways. J Cell Biochem. 2018;119(8):6723-6731.

5. Zhang Sumei, Shi Rui, Chen Shaolong, Wei Xiang, Zhu Huaqing, Zhou Qing, Wang Yuan. ATRA inhibits SGC7901 cell proliferation by regulating caveolin-1 location via ERK/MAPK pathway. Oncology letters. 2018;15(2):1523-1528.

6. Qi Yinliang, Wang Mei , Ruan Jianfeng, Dai Yuanchang, Zhou Qing, Zhang Sumei, Wang Yuan, Gui Shuyu. Effects of Hyperbaric Oxygen Treatment on Gastric Cancer Cell Line SGC7901. Biomed Rep. 2017;6(4):475-479.

7. Zhang Sumei, Chen Shaolong, Wei Xiang, Qi Yinliang, Zhou Qing, Wang Yuan. Endocan reduces the malign grade of gastric cancer cells by regulating associated proteins expression. Tumour Biol. 2016. 37:14915-14921.

8. Xu Zhe, Zhang Sumei, Zhou Qing, Wang Yuan, Xia Ruixiang. Endocan, a potential prognostic [and] diagnostic biomarker of acute leukemia. Mol Cell Biochem. 2014; 395: 117-123.

9. Zhang Sumei, Qi Yinliang, Zhang Haitao, He Wei,  Zhou Qing, Gui Shuyu, Wang Yuan. Melatonin inhibits cell growth [and] migration, but promotes apoptosis in gastric cancer cell line, SGC7901. Biotech Histochem. 2013; 88(6): 281-289.

10. Zhang Sumei, Zuo Li, Gui Shuyu, Zhou Qing, Wei Wei, Wang Yuan. Induction of cell differentiation [and] promotion of endocan gene expression in stomach cancer by melatonin. Mol Biol Rep. 2012: 39(3): 2843-2849.

11. Zhang Sumei, Zuo Li, Zhou Qing, Gui Shuyu, Shi Rui, Wu Qiang, Wei Wei, Wang Yuan. Expression [and] distribution of endocan in human tissues. Biotech Histochem. 2012; 87(3): 172-178.

12. Zuo Li, Zhang Sumei, Hu Ruolei, Zhu Huaqing, Zhou Qing, Gui Shuyu, Wu Qiang, Wang Yuan. Correlation between expression [and] differentiation of endocan in colorectal cancer. World J Gastroenterol. 2008;14(28):4562-4568.

13. 魏翔，陈绍龙，贾宁，周青，李静静，张素梅，汪渊. 全反式维甲酸对人胃腺癌细胞株SGC-7901凋亡的影响。安徽医科大学学报. 2017 ; 52(8):1119-1122.

14. 陈绍龙，魏翔，王怡，周青，张素梅，汪渊.  ESM-1 在低氧环境下胃腺癌细胞中的表达及意义。安徽医科大学学报. 2017 ; 52(1): 23-26.

1. 2012年安徽省省级科技成果奖    安徽省科学技术厅   第三完成人

2. 2016年合肥市科学技术进步奖三等奖   合肥市人民政府  第三完成人