主要从事慢性疼痛及其相关的焦虑和抑郁产生的神经机制，聚焦大脑神经环路的工作原理和发生异常的分子生物学基础，并研究镇痛的药物治疗和物理治疗策略。本研究组与中国科学技术大学脑功能与脑疾病重点实验室张智教授课题组长期合作。研究包括神经科学领域最前沿的神经病毒示踪和神经调控等技术描绘神经环路精细结构，采取单细胞测序等分子生物学技术揭示神经功能异常的分子机制。相关研究成果发表于Progress in Neurobiology、Translational Psychiatry、Journal Biological Chemistry和Neuroscience等SCI高影响力期刊10余篇。

教育经历

2024.07-至今       安徽医科大学 基础医学院教授          博士生导师

2023.12-至今       安徽医科大学 基础医学学院教授       硕士生导师

2018.12-2023.11 安徽医科大学 基础医学学院副教授    硕士生导师

2017.08-2019.08 中国科学技术大学 生命科学学院        博士后

2013.09-2017.06 中国科学技术大学 生命科学学院        博士

2002.09-2005.07 安徽大学生命科学学院 生物化学专业  硕士

1997.09-2001.07 安徽大学生命科学学院 生物化学专业  本科

1、2017.01-2019.12 国家自然科学基金委青年基金项目，中央杏仁核G9a表观遗传调控慢性疼痛形成，项目主持人；

2、2021.01-2022.12 安徽省教育厅自然科学研究项目，MeCP2调控疼痛传代的神经机制研究，项目主持人；

3、2021.12-2026.11 科技部“脑科学与类脑研究”重大项目，感知觉与情绪相互作用的神经环路机制，子课题项目骨干；

4、2024.01-2027.12 国家自然科学基金委面上项目，靶向感知觉系统干预疼痛的神经环路结构和功能研究，项目主持人。

[1] Wan-Ying Dong, Xia Zhu, Hao-Di Tang, Ji-Ye Huang, Meng-Yu Zhu,Ping-Kai Cheng, Hao Wang, Xi-Yang Wang, Haitao Wang, Yu Mao, Wan Zhao,Yan Zhang, Wen-Juan Tao*& Zhi Zhang*; Brain regulation of gastric dysfunction induced by stress, nature metabolism, 5, 1494–1505 (2023).

[2] Peng Cao, Mingjun Zhang, Ziyun Ni, Xiang-Jie Song, Chen-Ling Yang, Yu Mao, Wenjie Zhou,Wan-Ying Dong, Xiaoqi Peng, Changjian Zheng, Zhi Zhang*, Yan Jin*, and Wenjuan Tao*, Green light induces antinociception via visualsomatosensory circuits, Cell Reports, 2023, 42, 112290.

[3] Zi-hua Song, Xiang-Jie Song, Chen-ling Yang, Peng Cao, Yu Mao, Yan Jin, Meng-yun Xu, Hai-tao Wang, Xia Zhu,Wei Wang, Zhi Zhang* and Wen-juan Tao*; Up-regulation of microglial chemokine CXCL12 in anterior cingulate cortex mediates neuropathic pain in diabetic mice, Acta Pharmacologica Sinica, 2023, 0:1-13.

[4] Xiang-Jie Song^#, Chen-Ling Yang^#, Danyang Chen,Yumeng Yang, Yu Mao, Peng Cao, Aijun Jiang, Wei Wang*, Zhi Zhang* and Wenjuan Tao*;Up-regulation of LCN2 in the anterior cingulate cortex contributes to neural injury-induced chronic pain, Frontiers in Cellular Neuroscience, 2023, 17:1140769.

[5] Wenjie Zhou; Chonghuan Ye; Haitao Wang; Yu Mao; Weijia Zhang; An Liu; Chen-Ling Yang; Tianming Li; Lauren Hayashi; Wan Zhao; Lin Chen; Yuanyuan Liu*; Wenjuan Tao*; Zhi Zhang*; Sound induces analgesia via corticothalamic circuits, Science, 2022, 377, 198–204.

[6] Yan Jin, Yu Mao, Danyang Chen, Yingju Tai, Rui Hu, Chen-Ling Yang, Jing Zhou, Lijian Chen, Xuesheng Liu, Erwei Gu, Chunhui Jia, Zhi Zhang*, and Wenjuan Tao*; Thalamocortical circuits drive remifentanil-induced postoperative hyperalgesia, Journal of Clinical Investigation, 2022, 132(24).

[7] Wenjie Zhou, Yanhua Li, Xiaojing Meng, An Liu, Yu Mao, Xia Zhu, Qian Meng, Yan Jin, Zhi Zhang*, and Wenjuan Tao*, Switching of delta opioid receptor subtypes in central amygdala microcircuits is associated with anxiety states in pain, J. Biol. Chem. 2021; 296, 100277.

[8] Wenjuan Tao^#, Changmao Chen^#,Yuping Wang^#, Wenjie Zhou, Yan Jin, Yu Mao, Haitao Wang, Likui Wang, Wen Xie, Xulai Zhang, Jie Li, Juan Li, Xiangyao Li, Zhen-Quan Tang, Chenhua Zhou, Zhizhong Z. Pan* and Zhi Zhang*, MeCP2 mediates transgenerational transmission of chronic pain, Progress in Neurobiology, 2020 Mar 18:101790.

[9] Yuping Wang, Peng Cao, Lisheng Mei, Weiwei Yin, Yu Mao, Chaoshi Niu,Zhi Zhang*and Wenjuan Tao*, Microglia in the primary somatosensory barrel cortex mediate trigeminal neuropathic pain, Neuroscience, 2019 Aug 21; 414: 299-310.

[10] Yuanzhong Kai, Yanhua Li, Yu Mao, Jie Li, Wen Xie, Shi Chen, Likui Wang, Juan Li, Zhi Zhang* and Wenjuan Tao*, A medial prefrontal cortex–nucleus acumens corticotropin-releasing factor circuitry for neuropathic pain-increased susceptibility to opioid reward, Translational Psychiatry, 2018 May 21; 8(1): 100.

[11] Wenjuan Tao^#, Wenjie Zhou, Yuping Wang, Tingting Sun, Haitao Wang, Zhi Zhang*and Yan Jin*, Histone deacetylase inhibitor-induced emergence of synaptic δ-opioid receptors and behavioral antinociception in persistent neuropathic pain, Neuroscience, 2016 Dec 17; 339: 54-63.

[12] Wenjuan Tao^#, Quan Chen, LuWang, Wenjie Zhou, Yunping Wang, Zhi Zhang* , Brainstem brain-derived neurotrophic factor signaling is required for histone deacetylase inhibitor-induced pain relief, Molecular Pharmacology, 2015 87(6): 1035-1041.