主要研究严重危害人类健康的重大神经系统疾病如脑卒中和脑小血管病，针对其缺乏有效的中枢性抗炎药物和治疗靶点等关键科学问题，基于脑血管疾病的免疫调控、胶质细胞反应、脑血管损伤、出血转化等病理机制，利用化学生物学手段发现脑卒中的新颖治疗靶点以及可能的小分子治疗药物。迄今，已在国内外著名学术期刊以第一作者身份和共同第一作者在Cell reports medicine、Pharmacological research和Translational Stroke Research上等杂志发表多篇SCI论文。目前主持安徽医科大学人才启动基金项目1项。

1. 管昕2024年引进人才科研启动经费，2024.12-2029.12，主持；

1. Xin Guan#, Sitong Zhu#, Jinqian Song, Kui Liu, Mei Liu, Luyang Xie, Yifang Wang, Jin Wu, Xiaojun Xu, Tao Pang. Inhibition of microglial CMPK2 ameliorates brain injury after acute ischemic stroke. Cell reports Medicine, 101522. 2 May. 2024.（IF：14.3）

2. Xin Guan#, Jianbing Wu#, Jiahui Geng, Duorui Ji, Dasha Wei, Yong Ling, Yihua Zhang, Guojun Jiang, Tao Pang, Zhangjian Huang. A Novel Hybrid of Telmisartan and Borneol Ameliorates Neuroinflammation and White Matter Injury in Ischemic Stroke Through ATF3/CH25H Axis. X. Translational Stroke Research, 2024;15(1):195-218. （IF：6.9）

3. Yunjie Wang#, Xin Guan#, Cheng-Long Gao#, Wenchen Ruan, Shunyi Zhao, Guoyin Kai,Fei Li,Tao Pang. Medioresinol as a novel PGC-1α activator prevents pyroptosis of endothelial cells in ischemic stroke through PPARα-GOT1 axis. Pharmacological research, 2021;169:105640. （IF：10.334）

4. Xin Guan#, Dasha Wei#, Zhuangzhuang Liang#, Luyang Xie, Yifang Wang, Zhangjian Huang, Jin Wu, Tao Pang. FDCA attenuates neuroinflammation and brain injury after cerebral ischemic stroke. Acs chemical neuroscience, 2023;14(20):3839-3854. （IF：5）

5. Xin Guan#, Yunjie Wang#, Guoyin Kai, Shunyi Zhao, Tingyu Huang, Youzhen Li, Yuan Xu, Luyong Zhang, Tao Pang. Cerebrolysin Ameliorates Focal Cerebral Ischemia Injury Through Neuroinflammatory Inhibition via CREB/PGC-1α Pathway. （IF：4.2）……