石宣明-安徽医科大学基础医学院

师资队伍

教授副教授博士后合作导师全体师资优秀人才

博士后合作导师

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师资队伍

博士后合作导师

石宣明

职称：教授

联系电话：--

email：xuanming.shi AT ahmu.edu.cn

研究方向：1、肿瘤的表观遗传和代谢调控；2、宿主与病原体的相互作用。建立包括RNA-seq、ChIP-seq、ATAC-seq、Ig-seq和Microbiome等的测序文库及分析流程，给合二代测序，利用自建服务器进行各种生物信息学分析，解析肿瘤、ALI及自身免疫性疾病的发病机制，并寻找特异性药物的作用靶点。

个人简历科研项目论文专著专利与技术许可荣誉与奖励

1995-1999 安徽大学生物化学专业本科

1999-2001 安徽丰原集团新药开发助理工程师

2001-2002 中科院微生物所研究助理

2002-2005 四川农业大学和中科院微生物所联合培养生物化学与分子生物学硕士

2005-2009 德国罗斯托克大学和来布尼兹动物研究所分子生物学博士

2010-2014 美国得州大学西南医学中心生理和发育系博士后

2015-2017 美国得州大学西南医学中心生理系讲师

2017-2020 美国得州大学西南医学中心分子遗传系Brown&Goldstein实验室讲师

2020-至今安徽医科大学基础医学院生化教研室教授

1. Zhu R., Kang Y., Li Q., Peng K., Shi X.#., Yin Z. #, Xuan Y. #, Alpha-tocopherol inhibits ferroptosis and promotes neural function recovery in rats with spinal cord injury via downregulating Alox15. Biomed Pharmacother. 2024 May 14;175:116734. doi: 10.1016/j.biopha.2024.116734. #共通讯.

2. Ding L. *, Jiang H. *, Li Q. *, Li Q., Zhang T.T., Shang L., Xie B., Zhu Y., Ding K, Shi X. #, Zhu T. #, Zhu Y. #, Ropivacaine as a novel AKT1 specific inhibitor regulates the stemness of breast cancer, J Exp Clin Cancer Res. 2024 Mar 25;43(1):90. doi: 10.1186/s13046-024-03016-9. #共通讯.

3. Deng, H., Guo, X., Feng, N., Luo, Y., Liu, B., Liu, S. #, Wu, J. #, Shi, X. #, Targeting H3K27me3 demethylase to inhibit Shh signaling and cholesterol metabolism in medulloblastoma growth. Frontiers in Oncology 2022 Dec, https://doi.org/10.3389/fonc.2022.1057147 (2022影响因子：5.7) #共通讯.

4. Fang, F., Goldstein, J. L., Shi, X., Liang, G., Brown, M. S., Unexpected role for IGF-1 in starvation: Maintenance of blood glucose. Proc Natl Acad Sci U S A, 2022. 119(32): p. e2208855119.

5. Kang Y, Li Q, Zhu R, Li S, Xu X, Shi X.#, Yin Z#. Identification of Ferroptotic Genes in Spinal Cord Injury at Different Time Points: Bioinformatics and Experimental Validation. Mol Neurobiol. 2022 Jul 7. doi: 10.1007/s12035-022-02935-y. #共通讯.

6. Yi, J., Shi, X., Xuan, Z., & Wu, J. (2021). Histone demethylase UTX/KDM6A enhances tumor immune cell recruitment, promotes differentiation and suppresses medulloblastoma. Cancer Lett, 499, 188-200. doi: 10.1016/j.canlet.2020.11.031.

7. Fang F., Shi, X. , Brown M.*, Goldstein J.L.*, Liang G. Growth Hormone Acts on Liver to Stimulate Autophagy, Support Glucose Production, and Preserve Blood Glucose in Chronically Starved Mice. Proc Natl Acad Sci U.S.A. (2019) 116(15) 7449-7454.

8. Han, Y., Xiong Y., Shi, X., Wu, J, Zhao Y., Jiang J*. Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karypherin-β2 nuclear import system. PLoS Biology 15 (8), e2002063.

9. Shi, X., Wang, Q., Gu, J., Xuan, Z., Wu, J.*, Brg1/SmarcA4 Coordinates Genetic and Epigenetic Networks Underlying Shh-type Medulloblastoma Development. Oncogene 2016 Apr 11. doi: 10.1038/onc.2016.108.

10. Shi, X., Zhan, X., Wu, J.#, A Positive Feedback Loop between Gli1 and Tyrosine Kinase Hck Amplifies Shh Signaling Activities in Medulloblastoma. Oncogenesis (2015) 4, e176; doi:10.1038/oncsis.2015.38.

11. Zhang, Z., Cao, M., Chang, C., Wang, C., Shi, X., Zhan, X., Birnbaum, S., Bezprozvanny, I., Huber, K., Wu, J.*, Autism-Associated Chromatin Regulator Brg1/SmarcA4 is Required for Synapse Development and MEF2-mediated Synapse Remodeling. Molecular and Cellular Biology 2015 Oct 12. pii: MCB.00534-15.

12. Shi, X., Zhang, Z., Zhan, X., Cao, M., Satoh, T., Akira, S., Shpargel, K., Magnuson, T., Wang, R., Wang, C., Ge, K., Wu, J.* (2014). An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth. Nature Communications 2014; 5:5425.

13. Shi, X., Metges, C.C., and Seyfert, H.-M.* (2013) Characterization of a far upstream located promoter expressing the acetyl-CoA carboxylase-alpha in the brain of cattle. Gene. 2013 Feb 25;515(2):266-71.

14. Shi, X., Metges, C.C., and Seyfert, H.-M.* (2012). Interaction of C/EBP and NF-Y factors constrains the promoter IA activity of the bovine acetyl-CoA carboxylase-alpha gene. BMC Molecular Biology 2012 Jun 27;13(1):21.

15. #Zhan, X., #Shi, X., Zhang, Z., Chen, Y., Wu, J.I.* (2011) Dual Role of Brg Chromatin Remodeling Factor in Shh Signaling during Neural Development. Proc Natl Acad Sci U.S.A. 2011 Aug 2;108(31):12758-63. # Co-first author.

16. Liu, S., Shi, X., Guenther, J., Bauer, I., Seyfert, H.-M.* (2011). Lingual Antimicrobial Peptide and IL-8 expression are oppositely regulated by the antagonistic effects of NF-kB p65 and C/EBPb in Mammary Epithelial Cells. Mol. Immunol. 2011 March 48(6-7):895-908.

17. Shi, X., Liu, S., Metges, C.C., and Seyfert, H.-M.* (2010). C/EBP-beta drives expression of the nutritionally regulated promoter IA of the acetyl-CoA carboxylase-alpha gene in cattle. Biochim. Biophys. Acta-gene regulatory mechanism 2010 1799:561-567.

18. Muráni, E., Ponsuksili, S., Seyfert, H.-M., Shi, X., and Wimmers, K.* (2009). Dual effect of a single nucleotide polymorphism in the first intron of the porcine Secreted phosphoprotein 1 gene: allele-specific binding of C/EBP beta and activation of aberrant splicing. BMC Molecular Biology 2009 Oct 21;10(1):96.