鲁云霞，副教授五级，硕士研究生导师，基础医学院综合实验中心主任，兼安徽省生物医学基础与应用科技公共服务平台负责人。早在博士研究生阶段，鲁云霞即在豹皮樟总黄酮降低2型糖尿病动物模型空腹及餐后血糖、改善胰岛素抵抗等领域做出过重要贡献。曾在美国University of Nebraska Medical Center作为访问学者，接收过系统正规的分子生物学培训。长期从事肥胖、糖尿病、骨质疏松等代谢性疾病及药物治疗的研究，积累了构建糖尿病、骨质疏松、衰老、皮肤外伤等相关动物模型的丰富经验，研究的中西药物有豹皮樟总黄酮、非诺贝特、辛伐他汀、利拉鲁肽、达格列净、白藜芦醇和丹蛭降糖胶囊等。

迄今，鲁云霞在Am J Chin Med, Life Sci, PLoS One, BBRC, Pharmacology, Endocrine, Biomed Pharmacother, Microvas Res., Front Pharmacol, Front Endocrinol等期刊上发表SCI论文20余篇，累计影响因子70分以上，中文期刊40余篇。受邀担任Phytomedicine, Clinical and Experimental Hypertension, PloS One，Clinical Phytoscience, FASBJ, Genes&Nutrition, Clinical Phytoscience, Digestive Diseases and Sciences, International Journal of Diabetes and Clinical Research, Nutrition,Scientific Report多个学术杂志的审稿人。

主要经历：

1986.09-1990.06  武汉大学,生物学系，生物化学专业  学士

1991.09-1994.06  武汉大学，生命科学学院，植物分子生物学专业  硕士

1994.07-1997.06  安徽医科大学，基础医学院，生化教研室，助教

1997.07-2004.06  安徽医科大学，基础医学院，生化教研室，讲师

2004.07-至今        安徽医科大学生化教研室     副教授

2005.07-2005.08  上海第二军医大学生化教研室，进修

2005.09-2010.06  安徽医科大学药学院药理学专业   博士

2011.07-2011.08  上海第二军医大学微生物学教研室，进修

2013.02-至今        中国微循环学会糖尿病与微循环分会委员

2014.07-2015.07  University of Nebraska Medical Center，visiting scholar

2020年-至今         CCI心血管俱乐部特约通讯员

1.安徽省教育厅自然科学基金一般项目，2型糖尿病人的蛋白质酪氨酸磷酸酶（PTP1B）的多态性分析（2006kj371B，主持）

2. 安徽医科大学博士启动基金，高脂诱导大鼠骨骼肌发生内质网应激的机制研究（XJ201013，主持）

3.安徽省自然科学基金面上项目，氧化-内质网应激通路在高脂致血管内皮损伤中的作用及非诺贝特的干预研究（1208085MH168，主持）

4. 国家中医临床研究基地业务建设科研专项课题，活性氧介导的内质网应激通路在脂毒性致血管内皮损伤中的作用及丹蛭降糖胶囊的干预研究国家中医药管理局科技司（JDZX2015129，主持）

5.安徽省高等学校自然科学研究项目重点项目，SIRT1的去乙酰化作用改善游离脂肪酸致动脉内皮细胞炎症的机制研究（KJ2017A186，主持）

6.安徽省自然科学基金面上项目，SIRT1改善脂毒性致血管内皮细胞TXNIP/NLRP3通路激活的机制研究（1808085MH233，主持）

7.国家自然科学基金，面向疲劳状态评价的人体热模型反问题研究（2020.01-2023.12, No.51976026，排名第二）

8.安徽省高等学校自然科学研究重大项目，基于大别山中药功能性整理的纯棉无纺布敷料研制与开发（KJ2021ZD0166，排名第三）

指导本科生获得的科研经费资助

1. 2017年地方高校国家级大学生创新创业训练计划项目，雌激素对骨骼肌脂肪酸代谢调控的机制研究（201710366019，指导教师）

2. 2019年地方高校省级大学生创新创业训练计划项目, 轻断食膳食"5+2"模式通过诱导自噬改善2型糖尿病大鼠肝脏胰岛素抵抗的机制探讨(S201910366030)

3. 2021年地方高校省级大学生创新创业训练计划项目,丹蛭降糖胶囊改善db/db小鼠肝脏组织焦亡的分子机制研究（S202110366024）

4. 2021年度临床医学(“5+3”一体化)专业“早期接触科研”训练计划立项项目，断血流提取物抑菌抗炎作用及结合新型纯棉无纺布敷料用于大鼠皮肤创口愈合的研究（2021-ZQKY-133，基础导师）

1.Yun-Xia Lu, Qiu Zhang, Jun Li, Yu-Xiu Sun, Ling-Yun Wang, Wen-Ming Cheng,  Xiang-Yang Hu. Antidiabetic effects of total flavonoids from Litsea Coreana Leve on fat-fed, streptozotocin-induced type 2 diabetic rats[J], Am J Chin Med, 2010, 38(4), 713–725.

2.Yunxia Lu,Lei Qian,Qiu Zhang,Bing Chen,Li Gui,Dake Huang,Guanjun Chen,Li Chen. Palmitate induces apoptosis in mouse aortic endothelial cells and endothelial dysfunction in mice fed high-calorie and high-cholesterol diets. Life Sci, 2013, 92 (24-26)：1165-73.

3. Zhengxuan Jiang,Kun Liang,Biqing Ding,Wei Tan,Jing Wang,Yunxia Lu,Yuxin Xu,Liming Tao. Hepatocyte growth factor genetic variations and primary angle-closure glaucoma in the han chinese population. PLoS One. 2013 Apr 9;8(4):e60950. doi: 10.1371/journal.pone. 0060950. Print 2013.

4. W Fang, J Zheng, C Chen, H Zhang,Y Lu, L Ma, G Chen. One-pot synthesis of porous Fe3O4 shell/silver core nanocomposites used as recyclable magnetic antibacterial agents. J Magn Magn Mater. 2014, 357: 1–6.

5. Yunxia Lu,Jingjing Cheng,Li Chen,Chaofei Li,Guanjun Chen,Li Gui,Bing Shen,Qiu Zhang. Endoplasmic reticulum stress involved in high-fat diet and palmitic acid-induced vascular damages and fenofibrate intervention. Biochem Biophys Res Commun. 2015; 458 (1): 1-7.

6. Zhang N, Lu Y, Shen X, Bao Y, Cheng J, Chen L, Li B, Zhang Q*. Fenofibrate treatment attenuated chronic endoplasmic reticulum stress in the liver of nonalcoholic fatty liver disease mice. Pharmacology. 2015;95(3-4):173-180.

7. Fang Dai，Tian Jiang，Ying-ying Bao，Guan-jun Chen，Li Chen, Qiu Zhang, Yun-xia Lu*. Fenofibrate improves high-fat diet-induced and palmitate-induced endoplasmic reticulum stress and inflammation in skeletal muscle. Life Sci, 2016, 157：158-167.

8. Li Chen, Ting Wang, Guanjun Chen, Nuojin Wang, Li Gui, Fang Dai, Zhaohui Fang, Qiu Zhang, Yunxia Lu*. Influence of resveratrol on endoplasmic reticulum stress and expression of adipokines in adipose tissues/adipocytes induced by high-calorie diet or palmitic acid. Endocrine. 2017, 55(3), 773-785.

9. Ting Wang, Xiaohuan Zhu, Fang Dai, Chaofei Li, Dake Huang, Zhaohui Fang,Qiu Zhang*,Yunxia Lu*. Effects of a standard high-fat diet with or without multiple deficiencies on bone parameters in ovariectomized mature rat. PLoS One. 2017 Sep 26;12(9):e0184983. 

10. Yunxia Lu*,Yong Chen,Rui Li,Quan Liu,Nuojin Wang,Yi Zhang,Bao Li,Zhaohui Fang. Protective effects of Danzhi jiangtang capsule on vascular endothelial damages induced by high-fat diet and palmitic acid，Biomed Pharmacother, 2018, 107, 1631-1640.

11.Yiqing Chen,Fang Dai,Yong He,Qin Chen,Quan Xia,Gang Cheng,Yunxia Lu, Qiu Zhang.Beneficial effects of hyperoside on bone metabolism in ovariectomized mice.Biomed Pharmacother. 2018, 107:1175-1182. doi: 10.1016/j.biopha.2018.08.069.

12.Quan Liu,Rui Li,Guanjun Chen,Jianming Wang,Bingfeng Hu,Chaofei Li,Xiaohuan Zhu,Yunxia Lu*. Inhibitory effect of 17β‑estradiol on triglyceride synthesis in skeletal muscle cells is dependent on ESR1 and not ESR2. Mol Med Rep, 2019,19: 5087-5096.

13. Yueping Wang, Lizhong Mu, Ying He, Yuanliang Tang, Chao Liu, Yunxia Lu, Lisheng Xu. Heat Transfer Analysis of Blood Perfusion in Diabetic Rats using a Genetic Algorithm. Microvas Res., 2020, 131, 104013.

14. Yajie Wei,Huimin Chen,Qingzhuo Chi,Ying He,Lizhong Mu,Chao Liu,Yunxia Lu. Synchronized research on endothelial dysfunction and microcirculation structure in dorsal skin of rats with type 2 diabetes mellitus. Med Biol Eng Comput. 2021; 59(5):1151-1166.

15. Nan Zhang, Chao Liu, Yi Zhang, Dongmei Xu, Li Gui, Yunxia Lu*, Qiu Zhang*. Liraglutide regulates lipid metabolism via FGF21- LKB1- AMPK- ACC1 pathway in white adipose tissues and macrophage of type 2 diabetic mice. Biochem Biophys Res Commun.2021, 548: 120-126.

16. Qiongqiong Cao, Dongmei Xu, Yong Chen, Yueming Long, Fang Dai, Li Gui, Yunxia Lu*. Sitagliptin Reduces Endothelial Dysfunction and Apoptosis Induced by High-fat Diet and Palmitate in Thoracic Aortas and Endothelial Cells via ROS-ER stress-CHOP Pathway. Front Pharmacol. 2021 Aug 31;12:670389.

17.Xia L, Cheng L, Jiang T, Liu C, Zhang S, Hu H, Dai F, Zhang Q, Lu Y. Estimation of the prevalence of type 2 diabetes in combination with diabetic kidney disease and identification of the associated factors in patients attending primary hospitals in Anhui Province, China. J Int Med Res. 2021 Oct;49(10):3000605211051225.

18.Zhao J, Liu L, Xin L, Lu Y, Yang X, Hou Y, Shi M, Han S, Zhou H, Liu Y, Fang Z, Li Y, Zhang G.The Protective Effects of a Modified Xiaohua Funing Decoction against Acute Liver Failure in Mice Induced by D-Gal and LPS. Evid Based Complement Alternat Med. 2022 Jan 13;2022:6611563. 

19.Fang Dai, Yi Zhang, Dongmei Xu, Chao Liu, Qiongqiong Cao, Li Gui, Yunxia Lu*, Qiu Zhang. Effects of long term diabetogenic high fat diet on bone in ovariectomized female rats. Biotechnic & Histochem. 2022, Jun 28;1-9. doi: 10.1080/10520295.2022.2083685. JCRQ4(2021), 1.834(2021).

20.Zhang Y, Liu C, Xu Y, Wang Y, Dai F, Hu H, Jiang T, Lu Y*, Zhang Q*. The management correlation between metabolic index, cardiovascular health, and diabetes combined with cardiovascular disease.Front Endocrinol (Lausanne). 2023 Jan 27;13:1036146.

21. Lanlan Cheng, Yijing Xu, Yueming Long, Fangmei Yu, Li Gui,Qiu Zhang*, Yunxia Lu*. Liraglutide attenuates palmitate-induced apoptosis via PKA/β-catenin/Bcl-2/Bax pathway in MC3T3-E1 cells.Naunyn-Schmiedeberg's Archives of Pharmacology. Accepted, doi:10.1007/s00210-023-02572-9

1. 2018年：指导药学本科生获第五届全国大学生基础医学创新论坛暨实验设计大赛三等奖（证书编号：NDC18A110000313）

2. 2017年：安徽医科大学校级“最美家庭”

3. 2016年：安徽医科大学校级“优秀教育工作者”

4. 2014年：安徽省省级“民盟省直基层组织优秀盟员”

5. 2013年：安徽医科大学校级“优秀班主任”