张贵阳 ，2018年毕业于南京大学，获理学博士学位，现为安徽医科大学基础医学院药理教研室副教授，硕士生导师。以第一作者/通讯作者在Nature Communications, Small，Advanced Healthcare Materials, Journal of Controlled Release, ACS Applied Materials & Interfaces, Chem Commun.等学术期刊发表论文20余篇。2022年受邀在ACS Applied Bio Materials和Advanced Therapeutics发表关于共价有机框架（COF）在小分子和蛋白药物递送上的Review以及以独立作者撰写的英文著作一章Covalent Organic Frameworks (2022，ISBN 978-1-80356-960-4)，研究论文入选“ESI高被引论文”，被引频次达632次，研究成果多次被国际同行评价为“Pioneered、First、Typical”等。指导硕士研究生获得国家奖学金，“互联网+”安徽省大学生竞赛银奖，安徽省药学会第十二届“曼迪新”药学优秀学术论文一等奖（2022）。授权专利三项。《亚洲药物制剂科学》（Asian Journal of Pharmaceutical Sciences，AJPS）青年编委(中科院一区，IF 10.2)。目前主要从事刺激响应COF材料的生物学应用研究，主要探索解决刺激响应COF衍生纳米材料用于生物分析和纳米医学应用研究。

工作经历：

2020.09 - 至今       安徽医科大学   基础医学院      校聘副教授   

2018.10 - 2020.09 南京大学   高分子化学与物理   在职研修学习 导师：贾叙东，袭锴教授

1. 博士科研启动经费 20万，主持，在研;

2. 安徽省高校自然科学研究项目：基于刺激-触发开关诱导聚集的苯硼酸脂生物响应材料的设计、制备与性能研究（KJ2019A0942），2019.7-2021.12, 6万，主持，已结；

3. 安徽医科大学基础与临床合作研究提升计划：(No.2021xkjT024), 2022.1-2024.12，20万，主持，在研;

4. 2022年安徽省转化医学研究院科研基金项目：主动透皮释药COFs贴片技术开发（2022zhyx-C13），2023.1-2025.12，8万，主持，在研。

入职安医大之后工作

1. Shengnan Zhou, Tian Tian, Tao Meng, Jin Wu, Danyou Hu, Qiaobo Liao, Jialu Zhuang, Hua Wang, * and Guiyang Zhang*Tumor-derived covalent organic framework nanozymes for targeted chemo-photothermal combination therapy. iScience, 2023, 26, 107348.

2. Tao Meng, Xinyue Wang, Shangshang Jiang, Si-rui Chen, Shengnan Zhou, Yuheng Zhu, Jin Wu, Danyou Hu*, Yuwen Yan, and Guiyang Zhang* Delivery of Small-Molecule Drugs and Protein Drugs by Injectable Acid-Responsive Self-Assembled COF Hydrogels for Combinatorial Lung Cancer Treatment. ACS Appl. Mater. Interfaces 2023, DOI: 10.1021/acsami.3c10074.

3. Book title: Covalent Organic Frameworks (ISBN 978-1-80356-960-4) 2022, DOI: 10.5772/intechopen.102264 Chapter title: Applications of Covalent Organic Frameworks (COFs) in Oncotherapy. Authors: Dr. Guiyang Zhang*

4. Shengnan Zhou†, Tao Meng†, Danyou Hu†, Yuheng Zhu, Chenguang Huang, Mengmeng Song, Shan Gao*, and Guiyang Zhang* Characteristic synthesis of a covalent organic framework and its application in multifunctional tumor therapy. ACS Applied Bio Materials 2022 5 (1), 59-81.

5. Xinyue Wang, Damani A. Lewis, Gang Wang, Tao Meng, Shengnan Zhou, Yuheng Zhu, Danyou Hu, Shan Gao, and Guiyang Zhang* Covalent Organic Frameworks as a Biomacromolecule Immobilization Platform for Biomedical and Related Applications. Advanced Therapeutics 2022, 2200053.

6. Chenguang Huang, Shengnan Zhou, Chen Chen, Xiaoyu Wang, Rui Ding, Yinshuang Xu, Ziwei Cheng, Zhuqing Ye, Lijun Sun, Zi-jian Wang, Danyou Hu, Xudong Jia, Guiyang Zhang*, and Shan Gao*. Biodegradable Redox-Responsive AIEgen-Based-Covalent Organic Framework Nanocarriers for Long-Term Treatment of Myocardial Ischemia/Reperfusion Injury. Small. 2022, 18, 2205062.

7. Shengnan Zhou, Danyou Hu, Zhirui Fang, Guiyang Zhang*. Covalent organic framework-based assembly systems for the intracellular delivery of proteins: opportunities and challenges. Nanomedicine (Lond.), 2021, 16 (15), 1259.

8. Guiyang Zhang, Bo Jiang, Chunyong Wu, Yanfeng Liu, Yidan He, Xin Huang, Wei Chen, Kai Xi,* Hongqian Guo*，Xiaozhi Zhao,* Xudong Jia*. Thin platelet-[like] COF nanocomposites for blood brain barrier transport and inhibition of brain metastasis from renal cancer. Journal of Materials Chemistry B 2020, 8, 4475.

9. Guiyang Zhang, Yan Ji, Xinle Li, Xiaoyun Wang, Mengmeng Song, Huilin Gou, Shan Gao*, Xudong Jia*. Polymer–Covalent Organic Frameworks Composites for Glucose and pH Dual-Responsive Insulin Delivery in Mice. Advanced Healthcare Materials 2020, 2000221.

10. Guiyang Zhang, Huilin Gou, Yanfeng Liu, Kai Xi*, Dechen Jiang, Xudong Jia*. pH-responsive PEG-chitosan/iron oxide hybrid nanoassemblies for low-power-assisted PDT/PTT combination therapy. Nanomedicine (Lond.), 2020, 15 (11), 1097-1112.

博士阶段工作

11. Guiyang Zhang, Xinle Li, Qiaobo Liao, Yanfeng Liu, Kai Xi*, Wenyu Huang*& Xudong Jia*. Water-dispersible PEG-curcumin/amine-functionalized covalent organic framework nanocomposites as smart carriers for in vivo drug delivery. Nature Communications, 2018, 9, 2785.

12. Guiyang Zhang, Qiaobo Liao, Yanfeng Liu, Li Wang, Huilin Gou, Can Ke, Xin Huang, Kai Xi* and Xudong Jia*. Secondary structure-induced aggregation by hydrogen peroxide: a stimuli-triggered open/close implementation by recombination, Nanoscale, 2018, 10, 5503-5514.

硕士阶段工作

13. Guiyang Zhang, Guhuan Liu, Ye Zhang*, Manqing Yan, Hong Bi*. TPP-modified protein-polymer bioconjugate as a mitochondria-targeting nanocarrier. Journal of Controlled Release. 2017, 259, E169-E170.

14. Guiyang Zhang, Lin Hu*, Kerong Zhu, Manqing Yan, Jian Liu, Jiaxiang Yang, Hong Bi*. Contribution of oligomer/carbon dots hybrid semiconductor nanoribbon to surface-enhanced Raman scattering property, Applied Surface Science, 2016, 364, 660–669.

15. Guiyang Zhang, Manqing Yan, Xiyao Teng, Hong Bi*, Yuyan Han, Mingliang Tian and Mingtai Wang. Formation of ultra-long nanoribbons by self-assembly of carbon dots and anionic oligomers for multi-colored fluorescence and electrical conduction, Chemical Communications, 2014,50, 10244-10247.

1. 袭锴; 张贵阳; 黄新; 刘彦峰; 孟震; 贾叙东 纳米药物载体、包含该纳米药物载体的载药体系及该载药体系的制备方法，专利号：ZL 2017 1 0951796.2

2. 多孔复合材料长效控糖体系、其制备方法和用途，高杉，张贵阳，宋梦梦，王小云 专利号：ZL 2019 1 1069 108.5

3. 负载抗肿瘤药物的纳米复合材料、纳米载药体系及制备与应用 张贵阳，胡丹优，周胜南，朱玉恒，孟涛 申请号：2022107953760