李维祖，男，1971年6月生，教授，博士，博士生导师，安徽医科大学基础医学院药理学教研室副主任，安徽省药理学会理事。主要从事药理学教学和科研工作，研究方向为神经药理学和内分泌药理学，主要从事自然衰老过程中皮层和海马神经元结构和功能变化及机制；慢性应激和糖皮质激素促进皮层和海马神经元损伤、衰老及人参皂苷Rg1抗衰老作用等的研究；黄芪甲苷对糖尿病及其并发症的作用及机制研究等。

教育经历

2007.09–2010.07  安徽医科大学, 药理学, 博士, 导师: 李卫平

2002.09–2005.07  安徽医科大学, 药理学, 硕士, 导师: 李卫平

1991.09–1996.07  兰州医学院, 预防医学, 学士

工作经历

2014.10-至今        安徽医科大学基础医学院               教授

2015.09-2016.09  北方德克萨斯大学健康科学中心     访问学者

2010.10-2014.09  安徽医科大学基础医学院               副教授

2005.07-2010.09  安徽医科大学基础医学院               讲师

1. 安徽省自然科学基金面上项目，2208085MH219，基于PLC-CaN-NFAT1信号通路研究人参皂苷Rg1抑制神经元Aβ生成的作用及机制，2022-01-01 至 2024-12-31，10万元，在研，主持；

2. 安徽省高校自然科学研究重大项目，KJ2020ZD14，化药 1 类新药—HY-021068 防治阿尔茨海默病的作用及机制研究， 2021/01-2023/12，20万元，在研，主持；

3. 安徽省科技重大专项，201903a07020025，化药1类缺血性脑卒中治疗新药——HY-021068 I期临床研究，2019.07- 2022.06，150万元，在研，参加；

4. 国家自然科学基金，面上项目，81970630，基于DAG/TRPC6/NFAT信号通路探讨游离脂肪酸联合高糖对糖尿病肾病肾小球纤维化的影响及其机制，2020.01- 2023.12，55万元，在研，参加；

5. 国家自然科学基金，面上项目，81671384，NADPH氧化酶介导的NLRP-1炎症小体激活在脑老化认知功能障碍中的作用及人参皂苷Rg1的调节作用，2017.01-2018.12，25万元，已结题，主持；

6. 国家自然科学基金，面上项目，81371329，糖皮质激素对海马神经元NLRP1炎症小体的调节作用及在海马神经元损伤中的作用， 2014.01-2017.12，70万元，已结题，主持；

7. 国家自然科学基金，面上项目，81173624，TRPC6蛋白在糖尿病肾病发病机制中的调控作用及其黄芪总苷的防治作用研究，2012.1-2015.12，56万元，已结题，参加；

1. Xianan Dong, Liangliang Kong, Lei Huang, Yong Su, Xuewang Li, Liu Yang, Pengmin Ji, Weiping Li, Weizu Li(*). Ginsenoside Rg1 treatment protects against cognitive dysfunction via inhibiting PLC–CN–NFAT1 signaling in T2DM mice. Journal of Ginseng Research, 2023, 47(3):458-468.

2. Kong L, Sun R, Zhou H, Shi Q, Liu Y, Han M, Li W, Qun S, Li W(*). Trpc6 knockout improves behavioral dysfunction and reduces Aβ production by inhibiting CN-NFAT1 signaling in T2DM mice. Exp Neurol. 2023 May; 363:114350.

3. Sun ZH, Liu F, Kong LL, Ji PM, Huang L, Zhou HM, Sun R, Luo J, Li WZ(*). Interruption of TRPC6-NFATC1 signaling inhibits NADPH oxidase 4 and VSMCs phenotypic switch in intracranial aneurysm. Biomed Pharmacother. 2023 May; 161:114480.

4. Han Y, Su Y, Han M, Liu Y, Shi Q, Li X, Wang P, Li W, Li W(*). Ginsenoside Rg1 attenuates glomerular fibrosis by inhibiting CD36/TRPC6/NFAT2 signaling in type 2 diabetes mellitus mice. J Ethnopharmacol. 2023 Feb 10;302(Pt A):115923.

5. Ji P, Shi Q, Liu Y, Han M, Su Y, Sun R, Zhou H, Li W(*), Li W. Ginsenoside Rg1 treatment alleviates renal fibrosis by inhibiting the NOX4-MAPK pathway in T2DM mice. Ren Fail. 2023 Dec;45(1):2197075.

6. Li X, Zhang H, Yang L, Dong X, Han Y, Su Y, Li W, Li W(*). Inhibition of NLRP1 inflammasome improves autophagy dysfunction and Aβ disposition in APP/PS1 mice. Behav Brain Funct. 2023 Apr 13;19(1):7.

7. Li X, Huang L, Kong L, Su Y, Zhou H, Ji P, Sun R, Wang C, Li W, Li W(*). Ginsenoside Rg1 alleviates learning and memory impairments and Aβ disposition through inhibiting NLRP1 inflammasome and autophagy dysfunction in APP/PS1 mice. Mol Med Rep. 2023 Jan;27(1):6.

8. 韩玉立, 董夏男, 杨柳, 李学望, 李艳, 李卫平, 李维祖(*). NOX4-NLRP3信号通路在衰老小鼠肾脏纤维化中的激活研究[J].安徽医科大学学报, 2022, 57(07):1022-1028.

9. Sun D, Gao G, Zhong B, Zhang H, Ding S, Sun Z, Zhang Y, Li W(*). NLRP1 inflammasome involves in learning and memory impairments and neuronal damages during aging process in mice. Behav Brain Funct. 2021 Dec 17;17(1):11.

10. Ding S, Yang L, Huang L, Kong L, Chen M, Su Y, Li X, Dong X, Han Y, Li W, Li W(*). Chronic glucocorticoid exposure accelerates Aβ generation and neurotoxicity by activating calcium-mediated CN-NFAT1 signaling in hippocampal neurons in APP/PS1 mice. Food Chem Toxicol. 2022 Oct; 168:113407.

11. Han Y, Li X, Yang L, Zhang D, Li L, Dong X, Li Y, Qun S, Li W(*). Ginsenoside Rg1 attenuates cerebral ischemia-reperfusion injury due to inhibition of NOX2-mediated calcium homeostasis dysregulation in mice. J Ginseng Res. 2022 Jul;46(4):515-525.

12. Zhang D, Ji P, Sun R, Zhou H, Huang L, Kong L, Li W(*), Li W. Ginsenoside Rg1 attenuates LPS-induced chronic renal injury by inhibiting NOX4-NLRP3 signaling in mice. Biomed Pharmacother. 2022 Jun; 150:112936.

13. Yang L, Zhou H, Huang L, Su Y, Kong L, Ji P, Sun R, Wang C, Li W, Li W(*). Stress level of glucocorticoid exacerbates neuronal damage and Aβ production through activating NLRP1 inflammasome in primary cultured hippocampal neurons of APP-PS1 mice. Int Immunopharmacol. 2022 Jun 28; 110:108972.

14. Sun Z, Li X, Yang L, Dong X, Han Y, Li Y, Luo J, Li W(*). SOCE-mediated NFAT1-NOX2-NLRP1 inflammasome involves in lipopolysaccharide-induced neuronal damage and Aβ generation. Mol Neurobiol. 2022; 59(5):3183-3205.

15. Zhang H, Su Y, Sun Z, Chen M, Han Y, Li Y, Dong X, Ding S, Fang Z, Li W, Li W(*). Ginsenoside Rg1 alleviates Aβ deposition by inhibiting NADPH oxidase 2 activation in APP/PS1 mice. J Ginseng Res. 2021 Nov;45(6):665-675.

16. Zhang Y, Ding S, Chen Y, Sun Z, Zhang J, Han Y, Dong X, Fang Z, Li W(*). Ginsenoside Rg1 alleviates lipopolysaccharide-induced neuronal damage by inhibiting NLRP1 inflammasomes in HT22 cells. Exp Ther Med. 2021 Jul; 22(1):782.

17. Shixin Ding, Han Zhang, Zhenghao Sun, Yuli Han, Yan Li, Xianan Dong, Yanyan Yin, Weiping Li(*), Weizu Li(*). Ginsenoside Rg1 protects against aging-induced renal interstitial fibrosis due to inhibition of tubular epithelial cells endoplasmic reticulum stress in SAMP8 mice[J]. Journal of Functional Foods, 2020, 72:104049.

18. Yong Su, Qingqing Chen, Yinghui Ju, Weizu Li(*), Weiping Li(*). Palmitate induces human glomerular mesangial cells fibrosis through CD36-mediated transient recept[or] potential canonical channel 6/nuclear fact[or] of activated T cell 2 activation[J]. Biochimica et Biophysica Acta (BBA) - Molecular [and] Cell Biology of Lipids, 2020, 12:1865.

19. Zhongyuan Wang; Yunfeng Zhu; Yanhua Zhang; Jie Zhang; Tianjiao Ji; Weizu Li(*); Weiping Li(*). Protective effects of AS-IV on diabetic cardiomyopathy by improving myocardial lipid metabolism in rat models of T2DM. Biomed Pharmacother. 2020, 127:110081.  

20. Xiaoyan Shen; Xianan Dong; Yuli Han; Yan Li; Shixin Ding; Han Zhang; Zhenghao Sun; Yanyan Yin; Weiping Li(*); Weizu Li(*). Ginsenoside Rg1 ameliorates glomerular fibrosis during kidney aging by inhibiting NOX4 [and] NLRP3 inflammasome activation in SAMP8 mice. Int Immunopharmacol. 2020, 82:106339. 

21. Sun, Lingling; Chen, Yali; Shen, Xiaoyan; Xu, Tanzhen; Yin, Yanyan; Zhang, Han; Ding, Shixin; Zhao, Yan; Zhang, Yuling; Guan, Yajun; Li, Weizu(*). Inhibition of NOX2-NLRP1 signaling pathway protects against chronic glucocorticoids exposure-induced hippocampal neuronal damage. International Immunopharmacology, 2019, 74: 105721. 

22. Ma Yuhong; Li Weizu(#); Shotorbani Parisa Yazdizadeh; Dubansky Brooke Hopkins; Huang Linjing; Chaudhari Sarika; Wu Peiwen; Wang Lei A; Ryou Myoung Gwi; Zhou Zhengyang; Ma Rong(*). Comparison of diabetic nephropathy between male [and] female eNOS(-/-) db/db mice. American Journal of Physiology - Renal Fluid [and] Electrolyte Physiology, 2019, 316(5): F889-F897. 

23. Su Yong; Chen Qingqing; Ma Keke; Ju Yinghui; Ji Tianjiao; Wang Zhongyuan; Li Weizu(*); Li Weiping(*). Astragaloside IV inhibits palmitate-mediated oxidative stress [and] fibrosis in human glomerular mesangial cells via downregulation of CD36 expression. Pharmacological Reports, 2019, 71(2): 319-329. 

24. Ju Yinghui; Su Yong; Chen Qingqing; Ma Keke; Ji Tianjiao; Wang Zhongyuan; Li Weizu(*); Li Weiping(*). Protective effects of Astragaloside IV on endoplasmic reticulum stress-induced renal tubular epithelial cells apoptosis in type 2 diabetic nephropathy rats. Biomedicine & Pharmacotherapy, 2019, 109: 84-92.

25. Xu Tan-Zhen; Shen Xiao-Yan; Sun Ling-Ling; Chen Ya-Li; Zhang Bi-Qiong; Huang Da-Ke; Li Wei-Zu(*). Ginsenoside Rg1 protects against H2O2induced neuronal damage due to inhibition of the NLRP1 inflammasome signalling pathway in hippocampal neurons in vitro. International Journal of Molecular Medicine, 2019, 43(2): 717-726. 

26. Tanzhen Xu; Lingling Sun; Xiaoyan Shen; Yali Chen; Yanyan Yin; Junyan Zhang; Dake Huang; Weiping Li; Weizu Li(*). NADPH oxidase 2-mediated NLRP1 inflammasome activation involves in neuronal senescence in hippocampal neurons in vitro. International Immunopharmacology, 2019, 69: 60-70. 

1. 安徽医科大学2016年度最具影响力十佳论文

2. 2013年、2018年获安徽医科大学优秀教师