近三年主要论文
1. Han G, Wang Y, Liu T, Gao J, Duan F, Chen M, Yang Y*, Wu C*. Salvianolic acid B acts against non‑small cell lung cancer A549 cells via inactivation of the MAPK and Smad2/3 signaling pathways. Mol Med Rep. 2022;25(5):184. doi: 10.3892/mmr.2022.12700.
2. Li L, Wang Q, He Y, Sun L, Yang Y*. Pang X*. Astragaloside IV suppresses migration and invasion of TGF-β1-induced human hepatoma Huh-7 cells by regulating Nrf2/HO-1 and TGF-β1/Smad3 pathways. NaunynSchmiedebergs Arch Pharmacol. 2022;395(4):397-405.
3. Gong Y, Li D, Li L, Yang J, Ding H, Zhang C, Wen G, Wu C, Fang Z, Hou S, Yang Y*. Smad3 C-terminal phosphorylation site mutation attenuates the hepatoprotective effect of salvianolic acid B against hepatocarcinogenesis. Food Chem Toxicol. 2021;147:111912.
4. Zhang C, Li L, Hou S, Shi Z, Xu W, Wang Q, He Y, Gong Y, Fang Z, Yang Y*. Astragaloside IV inhibits hepatocellular carcinoma by continually suppressing the development of fibrosis and regulating pSmad3C/3L and Nrf2/HO-1 pathways. J Ethnopharmacol. 2021,279:114350.
5. Yang J, Gong Y, Xu W, Li L, Shi Z, Wang Q, He Y, Zhang C, Luo C, Fang Z, Y, Yang Y*. Smad3 gene C-terminal phosphorylation site mutation exacerbates CCl4-induced hepatic fibrogenesis by promoting pSmad2L/C-mediated signaling transduction. NaunynSchmiedebergs Arch Pharmacol. 2021; 394(8): 1779-86.
6. Hu X, Han D, Wang Y, Gu J, Wang X, Jiang Y, Yang Y*, Liu J*. Phospho-Smad3L promotes progression of hepatocellular carcinoma through decreasing miR-140-5p level and stimulating epithelial-mesenchymal transition. Digest Liver Dis. 2021, 53: 1343-51
7. Tao X, Li D, Zhang C, Wen G, Wu C, Xu Y, Kan Y, Lu W, Ding H, Yang Y*. Salvianolic acid B protects against acute and chronic liver injury by inhibiting Smad2C/L phosphorylation. Exp Ther Med. 2021;21(4):341.
8. Ding H, Fang M, Gong Y, Li D, Zhang C, Wen G, Wu C, Yang J, Yang Y*. Smad3 gene C-terminal phosphorylation site mutation aggravates CCl4-induced inflammation in mice. J Cell Mol Med. 2020, 24: 7044-54.
9. Yang J, Yang Y, Zhang C, Li J*, Yang Y*. Epigenetic silencing of LncRNA ANRIL enhances liver fibrosis and HSC activation through activating AMPK pathway. J Cell Mol Med. 2020, 24: 2677-87.
10. Gong Y, Yang Y*. Activation of Nrf2/AREs-mediated antioxidant signaling, and suppression of profibrotic TGF-β1/Smad3 pathway: a promising therapeutic strategy for hepatic fibrosis - A review. Life Sciences, 2020, 256: 117909.
11. Lu W, Mei J, Yang J, Wu Z, Liu J, Miao P, Chen Y, Wen Z, Zhao Z, Kong H, Wu C, Yang Y*, Chen M*. ApoE deficiency promotes non-alcoholic fatty liver disease in mice via impeding AMPK/mTor mediated autophagy. Life Sciences, 2020, 252: 117601.
12. She Q, Shi P, Xu S, Xuan H, Tao H*, Shi K*, Yang Y*. DNMT1 Methylation of LncRNA GAS5 Leads to Cardiac Fibroblast Pyroptosis via Affecting NLRP3 Axis. Inflammation, 2020, 43: 1065-76.
13. Wu C, Chen W, Din H, Li D, Wen G, Zhang C, Lu W, Chen M, Yang Y*. Salvianolic acid B exerts anti-liver fifibrosis effffects via inhibition of MAPK mediated phospho-Smad2/3 at linker regions in vivo and in vitro. Life Sciences, 2019, 239:116881.
14. Wu C, Chen W, Fang M, Boye A, Tao X, Xu Y Hou S, Yang Y*. Compound Astragalus and Salvia miltiorrhiza extract inhibits hepatocellular carcinoma progression via miR-145/miR-21 mediated Smad3 phosphorylation. J Ethnopharmacol, 2019, 231:98-112.