沈玉先，博士，二级教授，博师生导师，博士后合作导师，国务院特殊政府津贴获得者，现为安徽医科大学生物药物研究所所长。教育部“新世纪优秀人才支持计划”入选者，省领军人才团队带头人、省“115”产业创新团队带头人、省学术技术带头人、省高校优秀科研团队带头人、省先进工作者、省创新争先奖获得者、全省教书育人楷模、全国妇女十二大代表等。Frontiers in Cell and Developmental Biology副主编、Journal of Pharmacological Sciences的编委、《中国药理学通报》编委。主持国家级课题10余项，其中包括区域创新联合基金重点项目1项，重大研究计划培育项目1项，面上项目7项。以通讯作者发表SCI论文60余篇，论文主要发表在Hepatology、Autophagy、Acta Pharmaceutica Sinica B、J Pineal Res等国际高影响力的期刊上。以第一完成人获省科学技术奖（自然科学类）一等奖1项，国家发明专利授权4项，转化1项。

    研究方向：功能性蛋白与药物作用靶点。

一、教育背景

1984.09-1989.06  安徽医科大学医学系本科/学士

1989.09-1992.06  安徽医科大学药理学专业研究生/硕士

1997.09-2000.06  安徽医科大学药理学专业研究生/博士

二、工作经历

1992.07-1995.06  安徽医科大学临床药理研究所助教

1995.07-1999.10  安徽医科大学临床药理研究所讲师

1999.11-2003.10  安徽医科大学临床药理研究所副教授

2003.02-2004.08  美国马利兰大学生物技术研究所博士后研究

2005.05-2008.12  中国科学技术大学生命科学院博士后研究

2003.11-2007.05  安徽医科大学临床药理研究所教授

2007.06-2010.06  省部共建教育部重点实验室教授

2009.01-2010.12   安徽医科大学护理学院副院长

2010.07-2012.05   安徽医科大学基础医学院教授，常务副院长

2012.06-2023.06   安徽医科大学基础医学院教授，院长

三、主要学术任职

中国药理学会抗炎免疫专业委员会委员、世界中医药学会联合会中医药免疫专业委员会常务理事；安徽省药理学会常务理事；安徽省色谱学会常务理事；Journal of Pharmacological Science编委、中国药理学通报编委、安徽医科大学学报编委、NatComm、FreeRadicalBioMed、BrainBehaviorandImmunity、SciRep等10 余种SCI源期刊的审稿人。

1.   国家自然科学基金区域创新发展联合基金重点项目：内质网应激蛋白MANF通过与过氧化还原酶6相互作用调节肝细胞的谱系定型及恶性转化研究，编号U21A20345，264万，2022/01-2025/12，主持。

2.   安徽省高校优秀科研创新团队：MANF肠道递送系统的研制及其在溃疡性肠炎中的应用研究，编号2022AH010046，200万，2023/01-2025/12，主持。

3.   安徽省高校协同创新项目：以MANF作为生物标志物的体外诊断试剂研发及其在慢性肝病诊断中的应用，编号GXXT-2021-069，100万，2021/-2023/12，主持。

4.   安徽医科大学科研水平提升计划项目：过氧化物氧化还原酶6通过调节MANF分泌抑制肝纤维化的作用及机制研究，编号2019xkjT001，30万，2020/01-2022/12，主持。

5.   国家自然科学基金面上项目：神经因子MANF介导的单核/巨噬细胞表型及功能的可塑性对肝纤维化的抑制作用及机制研究，编号81973336，55万，2020/01-2023/12，主持。

6.   国家自然科学基金面上项目：肝细胞源性神经营养因子MANF经外泌体靶向HSCs的抗肝纤维化作用及机制研究，编号81673438，60万，2017/01-2020/12，主持。

7.   安徽省转化医学研究院科研基金项目：基于新型神经营养因子MANF的双级靶向纳米递送系统的设计及其在缺血性脑卒中治疗中的应用，编号2017zhyx34，30万，2018/01-2020/12，主持。

8.   安徽省领军人才团队项目：慢性应激与重大疾病研究， 400万，2017/01-2018/12，主持。

9.   国家重点研发计划重大慢性非传染性疾病防控研究项目：基于单细胞基因表达谱的神经环路解析，编号2016YFC1305902，36万，2016/09-2020/12，主持。

10. 国家自然科学基金面上项目：新型神经营养因子MANF 对肝细胞癌的抑制作用及其机制研究，编号81372576，85万，2014/01-2017/12，主持。

11. 国家自然科学基金重大研究计划（培育项目）：内质网应激在乙型肝炎-肝硬化-肝癌转化过程中的调节机制及相关药物作用靶分子筛选，编号91129729，80万，2012/01-2014/12，主持。

12. 国家自然科学基金面上项目：炎症诱导的ARMET转录激活及其对NF-κB信号通路的调节机制，编号81173074，63万，2012/01-2015/12，主持。

13. 教育部博士点基金（博导类）：炎症诱导的ARMET转录激活及其对NF-κB信号通路的调节机制，编号20113420110004，12万，2012/01-2014/12，主持。

14. 国家自然科学基金面上项目：内质网应激蛋白ARMET对关节炎滑膜细胞过度增殖的负性调控，编号81072651，10万，2011/01-2011/12，主持。

15. 国家自然科学基金面上项目：泛素连接酶Hrd1介导的tau蛋白降解，编号30772557，34万，2008/01-2010/12，主持。

16. 安徽省科技攻关计划：内质网应激蛋白stresslin检测方法的建立及临床应用，编号07010300191，15万，2007/01-2009/12，主持。

17. 国家自然科学基金面上项目：泛素连接酶hHrd1对1-抗胰蛋白酶Z变异型的降解的调控机制，编号30572219，27万，2006/01-2008/12，主持。

18. 教育部重点项目：泛素连接酶 hHrd1和异常磷酸化tau功能性相互作用研究，编号206067，8万，2006/01-2008/12，主持。

19. 教育部“ 新世纪优秀人才支持计划”Z ：泛素-蛋白酶体通路调控1-抗胰蛋白酶Z变异型的降解，编号NCET-04-0589，50万，2005/01-2007/12，主持。

20. 中国博士后基金一等资助：泛素连接酶 hHrd1和异常磷酸化tau功能性相互作用研究，编号2005038011，3万，2005/01-2007/12，主持。

1.   Hou C, Wang D, Zhao MX, Ballar P, Zhang XR, Mei Q, Wang W, Li X, Sheng Q, Liu J, Wei CS, Shen YJ, Yang Y, Wang P, Shao JT, Sun Y*, Shen YX*. MANF brakes TLR4 signaling by competitively binding S100A8 with S100A9 to regulate macrophage phenotypes in hepatic fibrosis. Acta Pharmaceutica Sinica B.  Jun-13, 2023. Accepted (IF=14.5).

2.   Yang L, Shen WW, Shao W, Zhao Q, Pang GZ, Yang Y, Tao XF, Zhang WP, Mei Q, Shen YX*. MANF ameliorates DSS-induced mouse colitis via restricting Ly6ChiCX3CR1int macrophage transformation and suppressing CHOP-BATF2 signaling pathway. Acta Pharmacol Sin. 2023 Jun; 44(6): 1175–1190 (IF=8.2).

3.   Shen WW, Yang L, Yang Y, Wang P, Tao XF, Shen YJ, Wang S, Shen YX*. PRDX6 promotes fatty acid oxidation via PLA2-dependent PPARα activation in rats fed high-fat diet. Antioxid Redox Signal. 2023 Feb 7 (IF=6.6).

4.   Chen H, Zhu T, Huang X, Xu WS, Di Z, Ma YY, Xue M, Bi SX, Shen YJ, Yu YY, Shen YX*, Feng LJ*. Xanthatin suppresses proliferation and tumorigenicity of glioma cells through autophagy inhibition via activation of the PI3K-Akt-mTOR pathway. Pharmacol Res Perspect. 2023 Feb; 11 (1): e1041.

5.   Tao XF, Wang D, Liang YY, Yang L, He EG, Zhou J, He YF, Liang JX, Wang P, Chhetri G, Li Q, Shen YJ, Shen YX*. PRDX6 inhibits hepatic stellate cells acti-vation and fibrosis via promoting MANF secretion. Biomedicine & Pharma-cotherapy 2022, 156,113931.（IF=7.5）

6.   Shen QY, Wang D, Xu HY, Wei CS, Xiao XY, Liu J, Shen YJ, Fang L, Feng LJ, Shen YX*. Mesencephalic astrocyte-derived neurotrophic factor attenuates acute lung injury via inhibiting macrophages' activation. Biomed Pharma-cother 2022, 150: 112943.（IF=7.5）

7.   Xie YJ, Nishijima Y, Zinkevich NS, Korishettar A, Fang J, Mathison AJ, Zim-mermann MT, Wilcox DA, Gutterman DD, Shen YX*, Zhang DX*. NADPH oxidase 4 contributes to TRPV4‑mediated endothelium‑dependent vasodilation in human arterioles by regulating protein phosphorylation of TRPV4 channels. Basic Res Cardiol 2022, 117(1): 24. (IF=9.5)

8.   Hou X#, Liu Q#, Gao YM#, Yong L, Xie HY, Li WT, Zhou YP, Liu J, Feng LJ, Xu L, Shen YX*, Wang H*. Mesencephalic astrocyte-derived neurotrophic factor reprograms macrophages to ameliorate acetaminophen-induced acute liver injury via p38 MAPK pathway. Cell Death Dis 2022, 13(2): 100.（IF=9.0）

9.   Xu HY, Jiao YH, Li SY, Zhu X, Wang S, Zhang YY, Wei YJ, Shen YJ, Wang W, Shen YX*, Shao JT*. Hepatocyte-derived MANF mitigates ethanol-induced liver steatosis in mice via enhancing ASS1 activity and activating AMPK pathway. Acta Pharmacol Sin. 2022, 44(1):157-168.（IF=8.2）

10. Zhao TT#, Dong FQ#, Hu XL, Xu YL, Wei WM, Liu R, Yu F, Fang WJ*, Shen YX*, Zhang ZP*. Dynamic Tracking of p21 mRNA in Living Cells by Sticky-Flares for Visual Evaluation of Tumor Treatment Effect. Nanoscale 2022; 14 (5): 1733-1741.（IF=6.7）

11. Liu C, Liu J, Shao JT, Huang C, Dai XL, Shen YJ, Hou WS, Shen YX*, Yu YQ*. MAGED4B Promotes Glioma Progression via Inactivation of the TNF α induced Apoptotic Pathway by Down regulating TRIM27 Expression. Neurosci Bull 2022, 39(2):273-291 (IF=5.6).

12. Zhao Q, Sheng MF, Wang YY, Wang XY, Liu WY, Zhang YY, Ke TY, Chen S, Pang GZ, Yong L, Ding Z, Shen YJ, Shen YX*, Shao W*. LncRNA Gm26917 reguates inflammatory response in macrophages by enhancing Annexin A1 ubiquitination in LPS-induced acute liver injury. Frontiers in Pharmacology 2022, 13:975250 (IF=5.6).

13. Li H, Wu ZS, Zhong RL, Zhang QK, Chen QX, Shen YX*. PRDX6 knockout restrains the malignant progression of intrahepatic cholangiocarcinoma.Med Oncol. 2022 Oct 8;39(12):250.（IF=3.738）

14. Ren CP#, Gao Y#, Zhang C#, Zhou C, Hong Y, Qu MS, Zhao ZR, Du YN, Yang L, Liu BY, Wang SY, Han MF*, Shen YX*, Liu Y*. Respiratory Mucosal Im-munity: Kinetics of Secretory Immunoglobulin A in Sputum and Throat Swabs From COVID-19 Patients and Vaccine Recipients. Front Microbiol 2022, 13: 782421.（IF=6.064）

15. Song MM*, Chen J, Ye SM, Lu DP, Zhang GY, Liu R, Shen YX*. Targeted de-livery of edaravone by liposomes for the treatment of ischemic stroke. Nanomedi-cine 2022, https://doi.org/10.2217/nnm-2021-0490.（IF=5.5）

16. Wang P, Yang Y, Pang GZ, Zhang CY, Wei CS, Tao XF, Liu J, Xu JM, Zhang WP*, Shen YX*. Hepatocyte-derived MANF is protective for rifampic-in-induced cholestatic hepatic injury via inhibiting ATF4-CHOP signal activation. Free Radic Biol Med 2021, 162:283-297 (IF=6.17).

17. Yang Y, Wang P, Zhang CY, Huang F, Pang GZ, Wei CS, Lv CM, Chhetri G, Jiang TC, Liu J, Shen YJ, Shen YX*. Hepatocyte-derived MANF alleviates he-patic ischemia-reperfusion injury via regulating endoplasmic reticulum stress- in-duced apoptosis in mice. Liver Int 2021, 41 (3): 623-639 (IF=5.175).

18. Hou C#, Mei Q#, Song XG, Bao Q, Li X, Wang D, Shen YX*. Mono-macrophage-Derived MANF Protects Against Lipopolysaccharide-Induced Acute Kidney Injury via Inhibiting Inflammation and Renal M1 Macrophages. Inflammation 2021, 44 (2): 693-703 (IF=5.1).

19. Liu J#, Wu ZS#, Han D, Wei CS, Liang YY, Jiang TC, Chen L, Sha MQ, Cao YJ, Huang F, Geng XP, Yu JS, Shen YJ, Wang H, Feng LJ, Wang D, Fang SY, Wang SY*, Shen YX*. MANF inhibits liver cancer via SUMOylation-related suppres-sion of NF-κB/Snail signaling pathway and epithelial-mesenchymal transition. Hepatology 2020, 71(4):1262-1278 (IF=17.425).

20. Chhetri G, Liang YY, Shao JT, Han D, Yang Y, Hou C, Wang P, Tao XF, Shen YJ, Jiang TC, Feng LJ, Shen YX*. Role of Mesencephalic Astrocyte-Derived Neu-rotrophic Factor in Alcohol-Induced Liver Injury. Oxid Med Cell Longev 2020, 2020: 9034864 (IF=5.076).

21. Ma YY, Di ZM, Cao Q, Xu WS, Bi SX, Yu JS, Shen YJ, Yu YQ, Shen YX*, Feng LJ*. Xanthatin induces glioma cell apoptosis and inhibits tumor growth via acti-vating endoplasmic reticulum stress-dependent CHOP pathway. Acta Pharmacol Sin 2020, 41: 404-414 (IF=4.01).

22. Zhang N#, Shen YJ#, Pang GZ, Chu SY, Han W, Mei Q, Hu XL, Dong FQ, Shen YX*, Zhao TT*. Ratiometric fluorescent nano-sensor for dosage-sensitive visu-al discrimination of glucose based on electron transfer mechanism. Microchem J 2020, 158: 105188 (IF=5.304).

23. Shao JT*, Zaro J, Shen YX*. Advances in Exosome-Based Drug Delivery and Tumor Targeting: From Tissue Distribution to Intracellular Fate. Int J Nanomedi-cine 2020, 15:9355–9371 (IF=6.4).

24. Xu RY, Pang GZ, Zhao Q, Yang L, Chen S, Jiang L, Shen YX*, Shao W*. The momentous role of N6‐methyladenosine in lung cancer. J Cell Physiol 2020, 236(5): 3244-3256 (IF=6.513).

25. Fei MY#, Song MM#, Wang P, Pang GZ, Chen J, Lu DP, Liu R, Zhang GY, Zhao TT, Shen YX*, Yu YQ*. Folic acid modified Fe3O4 nanoclusters by a one-step ultrasonic technique for drug delivery and MR imaging. RSC Adv 2020, 10(9), 5294-5303 (IF=3.361).

26. Xu SC, Di ZM, He YF, Wang RJ, Ma YY, Sun R, Li J, Wang T, Shen YJ, Fang SY, Feng LJ*, Shen YX*. Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against Aβ toxicity via attenuating Aβ-induced endoplasmic re-ticulum stress, J Neuroinflammation 2019, 16(1):35.

27. Hou C#,Wang D#, Li X, He YF, Wei CS, Jiang R, Liu J , Feng LJ, Shen YX*. MANF regulates splenic macrophage differentiation in mice. Immunol Lett 2019, 212: 37-45.

28. Shi TL, Zhang L, Cheng QY, Yu JS, Liu J, Shen YJ, Feng XJ, Shen YX*. Xan-thatin induces apoptosis by activating endoplasmic reticulum stress in hepatoma cells. Eur J Pharmacol 2019, 843: 1–11.

29. Feng LJ#, Murugan M#, Bosco DB, Liu Y, Peng JY, Worrell GA, Wang HL, Ta LE, Richardson JR, Shen YX*, Wu LJ*. Microglial Proliferation and Monocyte Infiltration Contribute to Microgliosis following Status Epilepticus, Glia 2019, 67(8): 1434-1448.

30. Xiang HH#, Song MM#, Fei MY, Wang RJ, Tao XF, Shen YX*, Yu YQ*. Facile synthesis of multifunctional nanocomposites with good compatibility for efcient dual mode T1 and T2 magnetic resonance imaging and gene delivery. Appl Na-nosci 2019, 9(8): 2019-2030.

31. He KW, Li JJ, Shen YX*, Yu YQ*. pH-Responsive polyelectrolyte coated gado-linium oxide-doped mesoporous silica nanoparticles (GdO@MSNs) for synergis-tic drug delivery and magnetic resonance imaging enhancement, J Mater Chem B 2019, 7(43): 6840-6854.

32. Bi SX, Li XH, Wei CS, Xiang HH, Shen YX*, Yu YQ*. The antitumour growth and antiangiogenesis effects of xanthatin in murine glioma dynamically evaluated by dynamic contrast‐enhanced magnetic resonance imaging. Phytother Res 2019, 33(1): 149-158.

33. Wu J, Wang H, Li Q, Guo QY, Tao SQ, Shen YX*, Wu ZS*. The oncogenic im-pact of RNF2 on cell proliferation, invasion and migration through EMT on mammary carcinoma. Pathol Res Pract. 2019; 215 (9): 152523.

34. Wang D, Hou C, Cao YJ, Cheng QY, Zhang L, Li H, Feng LJ, Shen YX*. XBP1 activation enhances MANF expression via binding to endoplasmic reticulum stress response elements within MANF promoter region in hepatitis B. Int J Bio-chem Cell Biol 2018, 99: 140-146.

35. Song MM, Xiang HH, Fei MY, Lu DP, Jiang TC, Yu YQ, Liu R*, Shen YX*. Facile fabrication of water-dispersible nanocomposites based on hexa-peri-hexabenzocoronene and Fe3O4 for dual mode imaging (fluorescent/MR) and drug delivery. RSC Adv 2018, 8(71): 40554-40563.

36. Wang CH, Jiang TC, Qiang WM, Zhang L, Feng LJ, Shen YJ, Shen YX*. Acti-vator protein 1 is a novel regulator of mesencephalic astrocyte derived neu-rotrophic factor tranion. Molecular Medicine Reports 2018, 18(5): 5765-5774.

37. Feng LJ, Zhang J, Zhu N, Ding Q, Zhang XJ, Yu JS, Qiang WM, Zhang ZT, Ma YY, Huang DK, Shen YJ, Fang SY, Yu YF, Wang HP, Shen YX*. Ubiqui-tin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z vari- ant/alpha-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy. Autophagy 2017, 13(4):686-702.

38. Zhang WP, Chen LH, Feng H, Wang W, Cai Y, Qi F, Tao XF, Liu J, Shen YJ, Ren XF, Chen X, Xu JM*, Shen YX*. Rifampicin-induced injury in HepG2 cells is alleviated by TUDCA via increasing bile acid transporters expression and en-hancing the Nrf2-mediated adaptive response. Free Radic Biol Med 2017,112: 24-35.

39. Zhang D, Li MM, Dong Y, Zhang XH, Liu XY, Chen ZM, Zhu YJ, Wang HM, Liu XW, Zhu JL, Shen YJ, Korner H, Ying SC*, Fang SY* and Shen YX*. 1α, 25-Dihydroxyvitamin D3 up-regulates IL-34 expression in SH-SY5Y neural cells. Innate Immun 2017, 23(7): 584-591.

40. Song MM*, Xu HL, Liang JX, Xiang HH, Liu R, Shen YX*. Lactoferrin modi-fied graphene oxide iron oxide nanocomposite for glioma-targeted drug delivery. Mater Sci Eng C Mater Biol Appl 2017, 77: 904-911.

41. Liu J, Tao XF, Zhang J, Wang P, Sha MQ, Ma Y, Geng XP, Feng LJ, Shen YJ, Yu YF, Wang SY, Fang SY, Shen YX*. Small ubiquitin-related modifier 1 is in-volved in hepatocellular carcinoma progression via mediating p65 nuclear translo-cation. Oncotarget 2016, 7(16): 22206-22218.

42. Wang XY, Song MM, Bi SX, Shen YJ, Shen YX*, Yu YQ*. MRI Dynamically Evaluates the Therapeutic Effect of Recombinant Human MANF on Ischemia/ReperfusionInjury in Rats. Int J Mol Sci 2016, 17(9): 1476.

43. Fang WJ, Han C, Zhang HB, Wei WM, Liu R, Shen YX*. Preparation of ami-no-functionalized magnetic nanoparticles for enhancement of bacterial capture ef-ficiency. RSC Adv 2016, 6(72): 67875-67882.

44. Chen LJ, Feng LJ, Wang X, Du J, Chen Y, Yang W, Zhou CY, Cheng L, Shen YJ, Fang SY, Li J*, Shen YX*. Mesencephalic astrocyte-derived neurotrophic factor is involved in inflammation by negatively regulating the NF-κB pathway. Sci Rep 2015, 5: 8133.

45. Liu J, Sha MQ, Wang QF, Ma Y, Geng XP, Gao YF, Feng LJ, Shen YJ, Shen YX*. Small ubiquitin-related modifier 2/3 interacts with p65 and stabilizes it in the cytoplasm in HBV-associated hepatocellular carcinoma. BMC Cancer 2015, 15: 675.

46. Liu J, Zhou CY, Tao XF, Feng LJ, Wang X, Chen LJ, Li CJ, Huang DK, Fang SY, Shen YX*. ER stress-inducible protein MANF selectively expresses in human spleen. Hum Immunol 2015, 76(11): 823-830.

47. Chen LJ, Wan LJ, Du J*, Shen YX*. Identification of MANF as a protein inter-acting with RTN1-C. Acta Biochim Biophys Sin (Shanghai) 2015, 47(2): 91-97.

48. Yang W, Shen YJ, Chen Y, Chen L, Wang L, Wang HP, Xu SC, Fang SY, Fu Y, Yu YQ*, Shen YX*. Mesencephalic astrocyte-derived neurotrophic factor pre-vents neuron loss via inhibiting ischemia-induced apoptosis. J Neurol Sci 2014, 344 (1-2): 129-138.

49. Wang LK, Tang WX, Jiang TC, Lu P, Li YH, Sun AM, Shen YJ, Chen Y, Wang HP, Zong ZJ, Wang YQ, Chen LJ, Shen YX*. Endoplasmic Reticulum Stress is involved in the Neuroprotective Effect of Propofol. Neurochem Res 2014; 39(9):1741-1752.

50. Wang JJ, Chen QY, Wang X, Zu BB, Xu JH, Xu YH, Zuo XB, Shen YJ, Wang J, Shen YX*. Deficiency of IRE1 and PERK Signal Pathways in Systemic Lupus Erythematosus. Am J Med Sci 2014, 348(6): 465-473.

51. Chen ZM, Zhu MY, Pan X, Zhu YJ, Yan H, Jiang TC, Shen YJ, Dong XW, Zheng N, Lu JS, Ying SC*, Shen YX*. Inhibition of Hepatitis B virus replication by SAMHD1. Biochem Biophys Res Commun 2014, 450(4): 1462-1468.

52. Feng LJ, Jiang TC, Zhou CY, Yu CL, Shen YJ, Li J*, Shen YX*. Activated mac-rophage-[like] synoviocytes are resistant to endoplasmic reticulum stress-induced apoptosis in antigen-induced arthritis. Inflamm Res 2014; 63(5): 335-346.

53. Wang L, Chen L, Wang QF, Wang LJ, Wang HB, Shen YJ, Li XH, Fu Y, Shen YX*, Yu YQ*. Circulating endothelial progenitor cells are involved in VEGFR-2-related endothelial differentiation in glioma. Oncol Rep 2014, 32(5): 2007-2014.

54. Chen ZL, Zhong YW, Wang Y, Xu S, Liu Z, Baskakov IV, Monteiro MJ, Kar-bowski M*, Shen YX*, Fang SY*. Ubiquitination-Induced Fluorescence Com-plementation (UiFC) for Detection of K48 Ubiquitin Chains In Vitro and in Live Cells. PLoS One 2013, 8(9): e73482.

55. Shen YJ#, Sun AM#, Wang YH, Cha DQ, Wang HP, Wang FC, Feng LJ, Fang SY*, Shen YX*. Upregulation of mesencephalic astrocyte-derived neurotrophic factor (MANF) in glial cells is associated with ischemia-induced glial activation. J Neuroinflammation 2012, 9: 254.

56. Shen YX*, Sun AM, Fang S, Feng LJ, Li Q, Hou HL, Liu C, Wang HP, Shen JL, Luo J, Zhou JN*. Hrd1 Facilitates Tau Degradation and Promotes Neuron Sur-vival. Curr Mol Med 2012, 12(2): 138-152.

57. Wang HP, Li Q, Shen YJ, Sun AM, Zhu XG, Fang SY, Shen YX*. The ubiquitin ligase Hrd1 promotes degradation of the Z variant alpha 1-antitrypsin and in-creases its solubility. Mol Cell Biochem 2011, 346(1-2): 137-145.

58. Yu YQ, Liu LC, Wang FC, Liang Y, Cha DQ, Zhang JJ, Shen YJ, Wang HP, Fang S, Shen YX*. Induction profile of MANF/ARMET by cerebral ischemia and its implication for neuron protection. J Cereb Blood Flow Metab 2010, 30(1): 79-91.

59. Feng LJ, Shen YX*, Sun AM, Shen YJ, Fang SY, Li J*. Endoplasmic reticulum stress is involved in okadaic acid-induced tau phosphorylation and neurotoxic ef-fects of okadaic acid. Neural Regen Res 2010, 5(20): 1534-1540.

60. Yue L, Shen YX*, Feng LJ, Liu LH, Chen FH, Wu Q, Wang Hua. Blockage of the formation of new blood vessels by recombinant human endostatin contributes to the regression of rat adjuvant arthritis. Eur J Pharmacol 2007, 567(1-2): 166-170.

61. Shen YX, Ballar P, Apostolou A, Doong H, Fang SY. ER stress differentially reg-ulates the stabilities of ERAD ubiquitin ligases and their substrates. Biochem Bi-ophys Res Commun 2007, 352(4): 919-924.

62. Shen YX*, Zhang GG, Liu LH, Wang H, Xu SY. Suppressive of effects of mel-atonin on amyloid  peptide-induced glial activation in rat hippocampus. Arch Med Res 2007, 38(3): 284-290.

63. Shen YX, Ballar P, Fang SY*. Ubiquitin ligase gp78 increases solubility and fa-cilitates degradation of the Z variant of alpha-1-antitrypsin. Biochem Biophys Res Commun 2006, 349(4): 1285-1293.

64. Yue L, Wang H, Liu LH, Shen YX*, Wei W*. Anti-adjuvant arthritis of recom-binant human endostatin in rats via inhibition of angiogenesis and proinflamma-tory factors. Acta Pharmacol Sin 2004; 25(9): 1182-1185.

65. Shen YX*, Xu SY, Wei W, Sun XX, Liu LH, Yang J, Dong C. The protective ef-fects of melatonin from oxidative damage induced by amyloid beta-peptide 25-35 in middle-aged rats. J Pineal Res 2002, 32(2): 85-89.

66. Shen YX*, Xu SY, Wei W, Wang XL, Wang H, Sun X. Melatonin blocks rat hippocampal neuronal apoptosis induced by amyloid beta-peptide 25-35. J Pineal Res 2002, 32(3): 163-167.

67. Shen YX*, Xu SY, Wei W, Sun XX, Yang J, Liu LH, Dong C. Melatonin reduces memory changes and neural oxidation damage in mice treated with D-galactose. J Pineal Res 2002; 32(3): 173-178.

68. Shen YX*, Wei W, Xu SY. Protective effects of melatonin on the cortical -hippocampal neurotoxicity induced by amyloid beta-peptide 25-35. Acta Phar-macol Sin 2002, 23(1): 71-76.

69. Shen YX*, Wei W, Yang J, Liu C, Dong C, Xu SY. Improvement of melatonin to learning and memory impairment induced by amyloid -peptide 25~35 in elder Rats. Acta Pharmacol Sin 2001, 22(9): 797-803.

出版专著

1. 全国普通高等医学院校药学类专业“十三五”规划教材《临床药理学》副主编；

2.《药理学》（案例版）副主编。

1. 国家发明专利授权：中脑星形胶质细胞源性神经营养因子在治疗溃疡性结肠炎中的应用。专利号：ZL202011500878.3。授权公告日：2022.10.14（沈玉先、杨琳、邵伟、陈滢、沈玉君）

2. 国家发明专利授权：中脑星形胶质细胞来源神经营养因子的药用用途。专利号：ZL201910122781.4。授权公告日：2022.4.12（沈玉先、沈启英、韦传胜、耿鹏程）

3. 国家发明专利授权：以MANF为靶点的物质在制备治疗肝内胆管癌产品中的应用。专利号：ZL201811306752.5。授权公告日：2021.9.24（沈玉先、李红、张晓节、吴正升）

4. 国家发明专利授权：基于MANF作为标记物的肝细胞癌和肝内胆管细胞癌鉴别产品及方法。专利号：ZL201710009432.2。授权公告日：2018.7.24（沈玉先、吴正升、李红、李庆、沈玉君）。该成果已于2022年5月25日上午与安徽华培生物科技有限公司签订科技成果转让协议，已300万金额完成转化。

教学科研奖励

1.   2022年获安徽省教学成果奖（研究生教育）一等奖，地方医学院校“四有三高”拔尖创新医学人才培养实践，第四完成人。

2.   2022年获安徽省教学成果奖（研究生教育）三等奖，构建科教协同育人共同体 培养基础医学拔尖创新人才，第一完成人。

3.   2018年度安徽省科学技术奖（自然科学类）一等奖，内质网应激对炎症的调节作用及其关键药物靶分子筛选，第一完成人。

4.   2014年安徽省科学技术奖（科技进步类）二等奖，COX-2抑制剂靶向治疗消化系肿瘤的关键技术与应用，第二完成人。

5.   2013年安徽省科学技术奖（科技进步类）二等奖，胶质瘤多模态磁共振成像的基础及临床应用，第三完成人。

6.   1998年获安徽省科学技术奖（自然科学类）二等奖，松果腺褪黑素抗炎免疫调节和镇痛作用及其机制研究，第四完成人。

7.   2019年指导学生获第五届安徽省“互联网+”大学生创新创业大赛高教主赛道金奖，国赛铜奖。

8.   2023年指导大学生参加“第九届全国大学生基础医学创新研究暨实验设计论坛”基础临床赛道东部赛区复赛创新组一等奖。

荣誉

1.  2022年获安徽省高校优秀科研创新团队带头人（第一批）

2.  2022获省教书育人楷模

3.  2021年获第二届安徽省创新争先奖

4.  2020年获国务院特殊津贴

5.  2019年入选安徽省115产业创新团队带头人

6.  2018年推选为中国妇女十二大代表

7.  2017 年获得“安徽省先进工作者”

8.  2017年入选安徽省领军人才团队带头人

9.  2015年入选省学术技术带头人（第五批）

10. 2007年入选省学术技术带头人后备人选（第五批）

11. 2007年获人才开发基金资助

12. 2004年入选教育部新世纪优秀人才支持计划（第一批）

13. 2003年入选省高校拔尖人才（第一批）

14. 2000年获中国药理学会施维雅优秀青年药理学工作者奖。