王雨辰-安徽医科大学基础医学院

师资队伍

教授副教授导师讲师全体师资

教授

首页

师资队伍

教授

王雨辰

职称：教授

联系电话：--

email：yuchen007@gmail.com

研究方向：1.T细胞在射血分数保留型心衰中的作用研究；2.肠道免疫微环境在调控心力衰竭中的作用研究；3.心衰过程中心脏免疫微环境调控的研究；

个人简历科研项目论文专著专利与技术许可荣誉与奖励

王雨辰教授2016年毕业于中国科学技术大学获细胞生物学博士学位，2016-2022年在美国加州大学洛杉矶分校(UCLA)医学院进行博士后研究，2022-2025年在UCLA医学院担任Assitant Project Scientist工作，主要研究领域为免疫微环境调控和心脏类疾病。通过系统遗传学等手段，聚焦体内多器官免疫微环境互作对心力衰竭的影响，以及T细胞在射血分数保留型心衰中的作用等。以第一作者身份将主要工作发表于Circulation Research, Journal of Experimental Medicine, Nature Communications等期刊；获美国发明专利1项；任Biomedicines杂志编委；曾获得2024年度美国心脏学会(AHA)编委会最佳期刊论文奖, 和2023年度UCLA生命科学杰出奖提名等荣誉。2025年7月加入安徽医科大学基础医学院，任独立PI，博士生导师。

1. YC Wang, YC Koay, C Pan, … Indole-3-Propionic Acid Protects against Heart Failure with Preserved Ejection Fraction. Circulation Research. Feb 16;134(4):371-389 (2024). IF=23.21.

2. YC Wang, Y Cao, C Pan, … Heterogeneity of small intestinal immune and epithelial cells and their cellular response network to a western diet. Journal of Experimental Medicine. 220(5): 1-26 (2023). IF=17.58.

3. YC Wang, X Wang, J Yu, F Ma, Z li … Targeting Monoamine Oxidase A-Regulated TAM Polarization for Cancer Immunotherapy. Nature Communications. 12, Article number: 3530 (2021). IF=17.69.

4. YC Wang, HD Ma, XY Yin, YH Wang, QZ Liu, JB Yang, QH Shi, B Sun, ... Forkhead Box O1 Regulates Macrophage Polarization Following Staphylococcus aureus Infection. Clin Rev Allergy Immunol. 51 (3), 353-369 (2016). IF=10.89.

5. Y Cao, YC Wang, Z Zhou, C Pan, Z Zhou, Y Meng, S Charugundla, …Liver-heart Crosstalk Mediated by Coagulation Factor XI (F11) Influences Heart Failure. Science. 22 Sep (2022). Vol 377, Issue 6613. IF=63.71.

6. Y Li, Y Zhou, J Yu, YJ Kim, M Li, D Lee, K Zhou, Y Chen, Y Zhu, YC Wang, … Generation of allogeneic CAR-NKT cells from hematopoietic stem and progenitor cells using a clinically guided culture method. Nature Biotechnology. May 14 (2024). IF=68.16.

7. E Zhu, J Yu, Y-R Li, F Ma, YC Wang, … Biomimetic cell stimulation with a graphene oxide antigen-presenting platform for developing T cell-based therapies. Nature Nanotechnology. September 23 (2024). IF=38.1.

8. Y Cao, C Pan, YC Wang, Z Zhou, V Jeian, Y Meng, G Campbell, … Identification of DNA Damage Repair Enzyme Ascc2 as Causal for Heart Failure with Preserved Ejection Fraction (HFpEF). Circulation, 055857R3, (2022). IF=39.92.

9. Y Cao, L Vergnes, YC Wang, C Pan, KC Krishnan, TM Moore, Z Zhou, S Charugundla … Sex Differences in Heart Mitochondria: Relationship to Diastolic Dysfunction … Nature Communications. 13, Article number: 3850 (2022). IF=17.69.

10. X Wang, B Li, Yu Jeong Kim, YC Wang, Z Li, J Yu, … Targeting monoamine oxidase A for T cell-based cancer immunotherapy. Science Immunology. May 14;6(59): eabh2383. (2021). IF=30.63.

11. Y Zhu, DJ Smith, Y Zhou, YR Li, J Yu, D Lee, YC Wang, S Di Biase, ... Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer. Cell Stem Cell. 25 (4), 542-557. e9 (2019). IF=24.63.

12. S Li, F Ma, T Yokota, G Garcia Jr., A Palermo, Y Wang, C Farrell, YC Wang, R Wu, Z Zhou, C Pan … Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2 induced systemic toxicity. JCI insight. Jan 25;6(2): e145027 (2021). IF=9.484.

13. Y-R Li, Y Zhou, Y Kim, Y Zhu, F Ma, J Yu, YC Wang, Chen X, Li Z, Zeng S, Wang X … Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy. Cell Rep. Med. Nov 16 (2021). IF=16.99.

14. S Di Biase, X Ma, X Wang, J Yu, YC Wang, DJ Smith, Y Zhou, Z Li, YJ Kim, ... Creatine uptake regulates CD8 T cell antitumor immunity. Journal of Experimental Medicine. 216 (12), 2869-2882 (2019). IF=17.58.

15. B Li, X Wang, IY Choi, YC Wang, S Liu, AT Pham, H Moon, DJ Smith, ... miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity. Journal of Clinical Investigation. 127 (10), 3702-3716 (2017). IF=19.46.