吴文宁，博士，安徽医科大学基础医学院药理学教研室教授，博士生导师，东南博士后合作导师，现为基础医学院研究生第二党支部书记。

教育工作经历

2000.09-2005.06       安徽中医药大学     学 士

2006.09-2011.06       华中科技大学         硕 博

2011.07-2014.10       安徽医科大学         讲 师

2017.11-2018.11       Mayo Clinic          访问学者

2014.11-2020.11       安徽医科大学         副教授

2020.12-至今             安徽医科大学         教 授

1.国家自然科学基金：小胶质细胞iRhom2/ADAM17-NLRP3炎症小体信号在颞叶癫痫发生中的作用及机制研究，2022.01-2025.12，55万，主持；

2.安徽医科大学科研水平提升计划项目：小胶质细胞iRhom2-NLRP3炎症小体信号在癫痫发生中的作用，2021.01-2023.12，30万，主持；

3.国家自然科学基金：NLRP1炎症小体-自噬信号在慢性不可预见性轻度应激致小鼠抑郁样行为中的作用，2017.01-2020.12，57万，主持；

4.国家自然科学基金：NLRP1炎症小体在酸中毒诱导皮层神经元损伤中的作用，2013.01-2015.12，23万，主持；

1. Wu WN, Li YJ, Wei YJ, Bosco DB, Xie ML, Zhao MG, Richardson JR, Wu LJ: Microglial depletion aggravates the severity of acute [and] chronic seizures in mice. Brain Behav Immun 2020.

2. Song AQ, Gao B, Fan JJ, Zhu YJ, Zhou J, Wang YL, Xu LZ, Wu WN*: NLRP1 inflammasome contributes to chronic stress-induced depressive-[like] behaviors in mice. J Neuroinflammation 2020, 17:178.

3. Fan JJ, Gao B, Song AQ, Zhu YJ, Zhou J, Li WZ, Yin YY, Wu WN*: Spinal cord NLRP1 inflammasome contributes to dry skin induced chronic itch in mice. J Neuroinflammation 2020, 17:122.

4. Zhou J, Lv XH, Fan JJ, Dang LY, Dong K, Gao B, Song AQ, Wu WN*: GYY4137 Promotes Mice Feeding Behavi[or] via Arcuate Nucleus Sulfur-Sulfhydrylation [and] AMPK Activation. Front Pharmacol 2018, 9:966.

5. Gao B, Wu Y, Yang YJ, Li WZ, Dong K, Zhou J, Yin YY, Huang DK, Wu WN*: Sinomenine exerts anticonvulsant profile [and] neuroprotective activity in pentylenetetrazole kindled rats: involvement of inhibition of NLRP1 inflammasome. J Neuroinflammation 2018, 15:152.

6. Zhang BQ, Zhang YD, Wu WN#, Xu TZ, Yin YY, Zhang JY, Huang DK, Li WZ: Chronic glucocorticoid exposure activates BK-NLRP1 signal involving in hippocampal neuron damage. J Neuroinflammation 2017, 14.

7. Chen HB, Wu WN#, Wang W, Gu XH, Yu B, Wei B, Yang YJ: Cystathionine-beta-synthase-derived hydrogen sulfide is required f[or] amygdalar long-term potentiation [and] cued fear memory in rats. Pharmacol Biochem Behav 2017, 155:16-23.

8. Hu W, Zhang YD, Wu WN#, Yin YY, Huang DK, Wang YC, Li WP, Li WZ: Chronic glucocorticoids exposure enhances neurodegeneration in the frontal cortex [and] hippocampus via NLRP-1 inflammasome activation in male mice. Brain Behavi[or] [and] Immunity 2016, 52:58-70.

9. Wang YC, Li WZ, Wu Y, Yin YY, Dong LY, Chen ZW, Wu WN*: Acid-sensing ion channel 1a contributes to the effect of extracellular acidosis on NLRP1 inflammasome activation in cortical neurons. J Neuroinflammation 2015, 12:246.

10. Wu WN, Wu PF, Zhou J, Guan XL, Zhang Z, Yang YJ, Long LH, Xie N, Chen JG, Wang F: Orexin-A activates hypothalamic AMP-activated protein kinase signaling through a Ca(2)(+)-dependent mechanism involving voltage-gated L-type calcium channel. Mol Pharmacol 2013, 84:876-887.

11. Wu WN, Wu PF, Chen XL, Zhang Z, Gu J, Yang YJ, Xiong QJ, Ni L, Wang F, Chen JG: Sinomenine protects against ischaemic brain injury: involvement of co-inhibition of acid-sensing ion channel 1a [and] L-type calcium channels. Br J Pharmacol 2011, 164:1445-1459.

12. Tong J, Wu WN, Kong X, Wu PF, Tian L, Du W, Fang M, Zheng F, Chen JG, Tan Z, Gong F: Acid-sensing ion channels contribute to the effect of acidosis on the function of dendritic cells. J Immunol 2011, 186:3686-3692.