樊祥山-安徽医科大学基础医学院

师资队伍

教授副教授博士后合作导师全体师资优秀人才

教授

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师资队伍

教授

樊祥山

职称：教授

联系电话：0551-62922867

email：fxs@ahmu.edu.cn

研究方向：1.胃癌异质性及其分子机制研究；2.肝癌肿瘤微环境及相关分子调控机制的研究；3.肝脏代谢相关疾病分子机制的研究。

个人简历科研项目论文专著专利与技术许可荣誉与奖励

樊祥山，医学博士，主任医师，校聘教授，博士生导师。现任安徽医科大学病理中心执行主任兼病理解剖学教研室主任和第一附属医院病理科主任，安徽医科大学病理专科联盟执行主任；目前担任中华医学会病理学分会青年委员会副主任委员和中青年病理科主任工作组副组长、中国抗癌协会肿瘤病理专委会常务委员兼胃肠肿瘤学组副组长和食管癌学组副组长、中国研究型医院学会超微与分子病理学专委会常委兼肝胆胰疾病学组组长、中国民族医药学会精准医学分会副秘书长、安徽省抗癌协会常务理事兼肿瘤病理专委会副主任委员、中国合格评定国家任何委员会ISO15189医学实验室认可评审专家。曾担任江苏省病理质控中心主任和南京市病理质控中心主任等职务。曾主持国家及省市级课题10项，作为PI承担国际或全国多中心临床试验17项；起草或执笔国家标准或指南4部；主/副主编专著或国家教材4部；以第一或通讯作者在EMBO Molecular Medicine、J Pathol等SCI杂志和中华系列杂志发表论文百余篇。

2023.07 - 至今，安徽医科大学病理中心/第一附属医院病理科，校聘教授、主任医师

2023.04 - 2024.06，美国杜克大学医学中心，病理学系，访问学者

2016.11 - 2023.07，南京大学，医学院附属鼓楼医院，副教授

2019.11 - 2023.07，南京大学，医学院附属鼓楼医院，主任医师

2011.10 - 2019.10，南京大学，医学院附属鼓楼医院，副主任医师

2014.08 - 2014.09，中国台北荣民总医院和新光医院，病理和实验医学部，访问学者

2011.11 - 2012.05，美国得州大学，MD Anderson癌症中心血液病理科，访问学者

2010.09 - 2013.06，南京大学医学院，外科学，博士研究生，导师：周晓军

2006.08 - 2011.09，南京大学，医学院附属鼓楼医院病理科，主治医师

2003.08 - 2006.07，南京大学，医学院附属鼓楼医院病理科，医师

2000.09 - 2003.06，东南大学，病理学与病理生理学，硕士研究生，导师：郑杰/张东生

1995.09 - 2000.06，滨州医学院，临床医学，学士

1. Pu X, Fu Y, Sun Q, Li L, Kwasi A, Ma Z, Fan X*, Sun B*. NTRK gene alterations were enriched in hepatoid or enteroblastic differentiation type of gastric cancer. J Clin Pathol. 2024 Aug 16;77(9):608-613. doi: 10.1136/jcp-2023-208865. PMID: 37451841.

2. Zhang H; Chen G; Feng X; Song H; Meng L; Fu Y; Yang Y; Fan Z; Ding Y; Du Z; Wang J; Yang L; Zhang J; Sun L; Liu Z; Zhang Z*; Li Q*; Fan X*; Targeting WDxR motif reprograms immune microenvironment and inhibits hepatocellular carcinoma progression, EMBO Molecular Medicine, 2023, 15(5): e15924. doi: 10.15252/emmm.202215924. PMID: 36947051.

3. Cai H, Feng X, Yin R, Zhao Y, Guo L, Fan X*, Liao J*. MIST: multiple instance learning network based on Swin Transformer for whole slide image classification of colorectal adenomas. J Pathol. 2023; 259(2): 125-135. doi: 10.1002/path.6027. PMID: 36318158.

4. Xue X, Sun Q, Jiang D, Wang X, Liu Y, Guo C, Liu L, Cheng N, Wang G*, Liu Y*, Hou Y*, Fan X*, Xue L*. The efficacy of additional surgical resection after endoscopic resection in pT1b esophageal squamous cell carcinoma: A multi-institutional retrospective study in China. Surg Endosc. 2023 Feb;37(2):871-880. doi: 10.1007/s00464-022-09459-5. Epub 2022 Aug 25. PMID: 36008639.

5. Ding Y*, Xu Y, Fu Y, Zhang H, Zhao L, Fan X*. Kruppel-[like] factor 13 inhibits cell proliferation of gastric cancer by inducing autophagic degradation of β-catenin. Discov Oncol. 2022 Nov 6;13(1):121. doi: 10.1007/s12672-022-00587-x. PMID: 36336731.

6. Sun Q, Fu Y, Chen X, Li L, Wu H, Liu Y, Xu H, Zhou G*, Fan X*, Xia H*. Prognostic Perspectives of STING and PD-L1 Expression and Correlation with the Prognosis of Epstein-Barr Virus-Associated Gastric Cancers. Gut Liver. 2022 Nov 15;16(6):875-891. doi: 10.5009/gnl210359. Epub 2022 May 25. PMID: 35611665.

7. Ding Y; Lv C; Zhou Y; Zhang H; Zhao L; Xu Y; Fan X*; Vimentin loss promotes cancer proliferation through up-regulating Rictor/AKT/β-catenin signaling pathway, Experimental Cell Research, 2021, 405(1): 112666. doi: 10.1016/j.yexcr.2021.112666. PMID: 34052237

8. Fu Y, Li Z, Gao F, Yang J, Wu H, Zhang B, Pu X*, Fan X*. MLH1/PMS2 Expression Could Tell Classical NTRK Fusion in Fluorescence In Situ Hybridization Positive Colorectal Carcinomas. Front Oncol. 2021 Apr 29;11:669197. doi: 10.3389/fonc.2021.669197. PMID: 33996597.

9. He F, Fu Y, Sun Q, Geng P, Zheng Z, Pu X, Shi J, Fan X*. Integrated clinicopathological and immunohistochemical analysis of gastric adenocarcinoma with hepatoid differentiation: an exploration of histogenesis, molecular characteristics, and prognostic markers. Hum Pathol. 2021 Sep;115:37-46. doi: 10.1016/j.humpath.2021.02.003. Epub 2021 Feb 23. PMID: 33636206.

10. Li Z, Pu X, He L, Fu Y, Li L, Xu Y, Guan W, Fan X*. Malignant Gastrointestinal Neuroectodermal Tumor in the Right Heart: A Report of an Extremely Rare Case Presenting With a Cardiac Mass. Front Cardiovasc Med. 2021 Sep 1;8:702215. doi: 10.3389/fcvm.2021.702215. PMID: 34540914.

11. Dong W, Zhu Y, Zhang Y, Fan Z, Zhang Z, Fan X*, Xu Y*. BRG1 Links TLR4 Trans-Activation to LPS-Induced SREBP1a Expression and Liver Injury. Front Cell Dev Biol. 2021 Mar 18;9:617073. doi: 10.3389/fcell.2021.617073. PMID: 33816466.

12. Hong W, Kong M, Qi M, Bai H, Fan Z, Zhang Z, Sun A, Fan X*, Xu Y*. BRG1 Mediates Nephronectin Activation in Hepatocytes to Promote T Lymphocyte Infiltration in ConA-Induced Hepatitis. Front Cell Dev Biol. 2021 Jan 21;8:587502. doi: 10.3389/fcell.2020.587502. PMID: 33553140.

13. Xu Y, Li Z, Shi J, Fu Y, Zhu L, Fan X*, Foo WC*. Clinicopathological features to distinguish malignant solitary fibrous tumors of the prostate from prostatic stromal tumors. Virchows Arch. 2021 Apr;478(4):619-626. doi: 10.1007/s00428-020-02909-2. Epub 2020 Aug 20. PMID: 32820389.

14. Chen B; Fan Z; Sun L; Chen J; Feng Y*; Fan X*; Xu Y; Epigenetic activation of the small GTPase TCL contributes to colorectal cancer cell migration and invasion, Oncogenesis, 2020, 9(9): 0-86. doi: 10.1038/s41389-020-00269-9; PMID: 32999272.

15. Fan Z, Kong M, Li M, Hong W, Fan X*, Xu Y*. Brahma Related Gene 1 (Brg1) Regulates Cellular Cholesterol Synthesis by Acting as a Co-factor for SREBP2. Front Cell Dev Biol. 2020 May 15;8:259. doi: 10.3389/fcell.2020.00259. PMID: 32500071.

16. Nie L, Li W, Xue L, Wang L, Shen Y, Fan X*. Submucosal gland neoplasms of the esophagus: an [update] and review. Esophagus. 2020 Oct;17(4):376-384. doi: 10.1007/s10388-020-00758-1. Epub 2020 Jul 3. PMID: 32621256.

17. Fan Z, Li N, Xu Z, Wu J, Fan X*, Xu Y*. An interaction between MKL1, BRG1, and C/EBPβ mediates palmitate induced CRP tranion in hepatocytes. Biochim Biophys Acta Gene Regul Mech. 2019 Sep;1862(9):194412. doi: 10.1016/j.bbagrm.2019.194412. Epub 2019 Jul 26. PMID: 31356989.